Statin Use is Associated with Better Cognitive Function in Elderly with Type 2 Diabetes

Anthony D. Heymann; Ramit Ravona-Springerc; Erin L. Moshier; James Godbold; Michal Schnaider Beeri

doi:10.3233/JAD-142571

Statin Use is Associated with Better Cognitive Function in Elderly with Type 2 Diabetes

Anthony D. Heymann^*, Ramit Ravona-Springerc, Erin L. Moshier, James Godbold, Michal Schnaider Beeri

^*Corresponding author for this work

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Abstract

The pleiotropic contribution of statins on cognition is uncertain. From 840 patients in the cohort from the Israel Diabetes and Cognitive Decline Study, we identified 61 non-statin users and compared them with 45 patients who had used statins at least 90% of the time. Analysis of covariance was performed to compare mean cognitive z-scores between statin users and non-users while adjusting for socio-demographic, diabetes-related, and cardiovascular covariates which included change in cholesterol by year. Overall cognition, memory, and executive function was found to be significantly better in statin users (p < 0.0008). This suggests a positive effect of statins on cognitive function of type 2 diabetes patients that is independent of cholesterol levels.

Original language	English
Pages (from-to)	55-59
Number of pages	5
Journal	Journal of Alzheimer's Disease
Volume	47
Issue number	1
DOIs	https://doi.org/10.3233/JAD-142571
State	Published - 2015

Keywords

All cognitive disorders/dementia
Alzheimer's disease
Case control studies
Diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3233/JAD-142571

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abstract = "The pleiotropic contribution of statins on cognition is uncertain. From 840 patients in the cohort from the Israel Diabetes and Cognitive Decline Study, we identified 61 non-statin users and compared them with 45 patients who had used statins at least 90% of the time. Analysis of covariance was performed to compare mean cognitive z-scores between statin users and non-users while adjusting for socio-demographic, diabetes-related, and cardiovascular covariates which included change in cholesterol by year. Overall cognition, memory, and executive function was found to be significantly better in statin users (p < 0.0008). This suggests a positive effect of statins on cognitive function of type 2 diabetes patients that is independent of cholesterol levels.",

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Statin Use is Associated with Better Cognitive Function in Elderly with Type 2 Diabetes

Abstract

Keywords

UN SDGs

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