TY - JOUR
T1 - Startle and prepulse inhibition as a function of background noise
T2 - A computational and experimental analysis
AU - Schmajuk, N. A.
AU - Larrauri, J. A.
AU - Hagenbuch, N.
AU - Levin, E. D.
AU - Feldon, J.
AU - Yee, B. K.
PY - 2006/6/30
Y1 - 2006/6/30
N2 - Schmajuk and Larrauri [Schmajuk NA, Larrauri JA. Neural network model of prepulse inhibition. Behav Neurosci 2005;119:1546-62.] introduced a real-time model of acoustic startle, prepulse inhibition (PPI) and facilitation (PPF) in animals and humans. The model assumes that (1) positive values of changes in noise level activate an excitatory and a facilitatory pathway, and (2) absolute values of changes in noise level activate an inhibitory pathway. The model describes many known properties of the phenomena and the effect of brain lesions on startle, PPI, and PPF. The purpose of the present study is to (a) establish the magnitude of startle and PPI as a function of pulse, prepulse, and background intensity, and (b) test the model predictions regarding an inverted-U function that relates startle to the intensity of the background noise.
AB - Schmajuk and Larrauri [Schmajuk NA, Larrauri JA. Neural network model of prepulse inhibition. Behav Neurosci 2005;119:1546-62.] introduced a real-time model of acoustic startle, prepulse inhibition (PPI) and facilitation (PPF) in animals and humans. The model assumes that (1) positive values of changes in noise level activate an excitatory and a facilitatory pathway, and (2) absolute values of changes in noise level activate an inhibitory pathway. The model describes many known properties of the phenomena and the effect of brain lesions on startle, PPI, and PPF. The purpose of the present study is to (a) establish the magnitude of startle and PPI as a function of pulse, prepulse, and background intensity, and (b) test the model predictions regarding an inverted-U function that relates startle to the intensity of the background noise.
KW - Background noise
KW - Computational model
KW - Neural networks
KW - Prepulse inhibition
KW - Startle
UR - http://www.scopus.com/inward/record.url?scp=33646529632&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2006.02.021
DO - 10.1016/j.bbr.2006.02.021
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AN - SCOPUS:33646529632
SN - 0166-4328
VL - 170
SP - 182
EP - 196
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 2
ER -