Abstract

Bioprosthetic valve dysfunction (BVD) and bioprosthetic valve failure (BVF) may be caused by structural or nonstructural valve dysfunction. Both surgical and transcatheter bioprosthetic valves have limited durability because of structural valve deterioration. The main objective of this summary of experts participating in a virtual workshop was to propose standardized definitions for nonstructural and structural BVD and BVF following aortic or mitral biological valve replacement with the goal of facilitating research reporting and implementation of these terms in clinical practice. Definitions of structural BVF, based on valve reintervention or death, underestimate the true incidence of BVF. However, definitions solely based on the presence of high transprosthetic gradient at a given echocardiogram during follow-up overestimate the incidence of structural BVD and BVF. Definitions of aortic or mitral structural BVD must therefore include the confirmation by imaging of permanent structural changes to the leaflets alongside evidence of deterioration in valve hemodynamic function at echocardiography follow-up.

Original languageEnglish
Pages (from-to)545-561
Number of pages17
JournalJournal of the American College of Cardiology
Volume80
Issue number5
DOIs
StatePublished - 2 Aug 2022

Funding

FundersFunder number
Department of Cardiology
Pi-Cardia
Abbott Laboratories
Medtronic
Wells Fargo
Edwards Lifesciences
Boston Scientific Corporation
Abbott Vascular
Biotronik
Leids Universitair Medisch Centrum

    Keywords

    • aortic valve replacement
    • bioprosthetic valve dysfunction (BVD)
    • bioprosthetic valve failure (BVF)
    • mitral valve replacement

    Fingerprint

    Dive into the research topics of 'Standardized Definitions for Bioprosthetic Valve Dysfunction Following Aortic or Mitral Valve Replacement: JACC State-of-the-Art Review'. Together they form a unique fingerprint.

    Cite this