@article{4bb57b845d2342dab350342a7076eb4c,
title = "Standalone cohesin as a molecular shuttle in cellulosome assembly",
abstract = "The cellulolytic bacterium Ruminococcus flavefaciens of the herbivore rumen produces an elaborate cellulosome system, anchored to the bacterial cell wall via the covalently bound scaffoldin ScaE. Dockerin-bearing scaffoldins also bind to an autonomous cohesin of unknown function, called cohesin G (CohG). Here, we demonstrate that CohG binds to the scaffoldin-borne dockerin in opposite orientation on a distinct site, relative to that of ScaE. Based on these structural data, we propose that the complexed dockerin is still available to bind ScaE on the cell surface. CohG may thus serve as a molecular shuttle for delivery of scaffoldins to the bacterial cell surface.",
keywords = "Cellulose degradation, Cohesin, Cohesin-dockerin complex, Dockerin, Rumen bacteria, Ruminococcus flavefaciens, Type III",
author = "Milana Voronov-Goldman and Oren Yaniv and Ozgur Gul and Hagar Yoffe and Orly Salama-Alber and Michal Slutzki and Maly Levy-Assaraf and Sadanari Jindou and Shimon, {Linda J.W.} and Ilya Borovok and Bayer, {Edward A.} and Raphael Lamed and Felix Frolow",
note = "Publisher Copyright: {\textcopyright} 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.",
year = "2015",
month = jun,
day = "3",
doi = "10.1016/j.febslet.2015.04.013",
language = "אנגלית",
volume = "589",
pages = "1569--1576",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Wiley-Blackwell",
number = "14",
}