TY - JOUR
T1 - Squamous cell carcinoma in perineal inflammatory disease
AU - Gur, Eyal
AU - Neligan, Peter C.
AU - Shafir, Raphael
AU - Reznick, Richard
AU - Cohen, Meir
AU - Shpitzer, Thomas
PY - 1997
Y1 - 1997
N2 - Four patients with squamous cell carcinoma of the perineal region were diagnosed and treated during the last 4 years in our institutions. The underlying diagnoses consisted of recurrent pilonidal disease, Crohn's disease, and hidradenitis suppurativa. In all patients, a pattern of a long- term inflammatory process was evident. Current concepts regarding the pathophysiology of a chronic inflammatory state and malignant transformation are reviewed. We conclude that regardless of the original pathology, all chronic inflammatory processes in the perineal region should be evaluated for malignant degeneration. A high index of suspicion may potentiate an early diagnosis, possibly improving the chance of cure.
AB - Four patients with squamous cell carcinoma of the perineal region were diagnosed and treated during the last 4 years in our institutions. The underlying diagnoses consisted of recurrent pilonidal disease, Crohn's disease, and hidradenitis suppurativa. In all patients, a pattern of a long- term inflammatory process was evident. Current concepts regarding the pathophysiology of a chronic inflammatory state and malignant transformation are reviewed. We conclude that regardless of the original pathology, all chronic inflammatory processes in the perineal region should be evaluated for malignant degeneration. A high index of suspicion may potentiate an early diagnosis, possibly improving the chance of cure.
UR - http://www.scopus.com/inward/record.url?scp=0030940251&partnerID=8YFLogxK
U2 - 10.1097/00000637-199706000-00016
DO - 10.1097/00000637-199706000-00016
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AN - SCOPUS:0030940251
SN - 0148-7043
VL - 38
SP - 653
EP - 657
JO - Annals of Plastic Surgery
JF - Annals of Plastic Surgery
IS - 6
ER -
