Spray freeze-drying as a solution to continuous manufacturing of pharmaceutical products in bulk

Merve B. Adali; Antonello A. Barresi; Gianluca Boccardo; Roberto Pisano

doi:10.3390/PR8060709

Spray freeze-drying as a solution to continuous manufacturing of pharmaceutical products in bulk

Merve B. Adali, Antonello A. Barresi, Gianluca Boccardo, Roberto Pisano^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Pharmaceutical manufacturing is evolving from traditional batch processes to continuous ones. The new global competition focused on throughput and quality of drug products is certainly the driving force behind this transition which, thus, represents the new challenge of pharmaceutical manufacturing and hence of lyophilization as a downstream operation. In this direction, the present review deals with the most recent technologies, based on spray freeze-drying, that can achieve this objective. It provides a comprehensive overview of the physics behind this process and of the most recent equipment design.

Original language	English
Article number	709
Journal	Processes
Volume	8
Issue number	6
DOIs	https://doi.org/10.3390/PR8060709
State	Published - 2020
Externally published	Yes

Keywords

Atomization
Continuous manufacturing
Freezing
Pharmaceuticals
Spray freeze-drying

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10.3390/PR8060709

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abstract = "Pharmaceutical manufacturing is evolving from traditional batch processes to continuous ones. The new global competition focused on throughput and quality of drug products is certainly the driving force behind this transition which, thus, represents the new challenge of pharmaceutical manufacturing and hence of lyophilization as a downstream operation. In this direction, the present review deals with the most recent technologies, based on spray freeze-drying, that can achieve this objective. It provides a comprehensive overview of the physics behind this process and of the most recent equipment design.",

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AB - Pharmaceutical manufacturing is evolving from traditional batch processes to continuous ones. The new global competition focused on throughput and quality of drug products is certainly the driving force behind this transition which, thus, represents the new challenge of pharmaceutical manufacturing and hence of lyophilization as a downstream operation. In this direction, the present review deals with the most recent technologies, based on spray freeze-drying, that can achieve this objective. It provides a comprehensive overview of the physics behind this process and of the most recent equipment design.

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Spray freeze-drying as a solution to continuous manufacturing of pharmaceutical products in bulk

Abstract

Keywords

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