Spontaneous self-assembly of designed cyclic dipeptide (Phg-Phg) into two-dimensional nano- and mesosheets

T. Govindaraju*, M. Pandeeswar, K. Jayaramulu, Garima Jaipuria, Hanudatta S. Atreya

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


In this study, we present the spontaneous self-assembly of designed simplest aromatic cyclic dipeptides of (L-Phg-L-Phg) and (D-Phg-L-Phg) to form highly stable two-dimensional (2D) nano- and mesosheets with large lateral surface area. Various microscopy data revealed that the morphology of 2D mesosheets resembles the hierarchical natural materials with layered structure. Solution and solid-state NMR studies on cyclo(L-Phg-L-Phg) revealed the presence of strong (N-H-O) hydrogen-bonded molecular chains supported by aromatic π-π interactions to form 2D mesosheets. Interestingly, cyclo(d-Phg-l-Phg) self-assembles to form single-crystalline as well as non-crystalline 2D rhomboid sheets with large lateral dimension. X-ray diffraction analysis revealed the stacking of (N-H-O) hydrogen-bonded molecular layers along c-axis supported by aromatic π-π interactions. The thermogravimetric analysis shows two transitions with overall high thermal stability attributed to layered hierarchy found in 2D mesosheets.

Original languageEnglish
Pages (from-to)487-492
Number of pages6
JournalSupramolecular Chemistry
Issue number7
StatePublished - Jul 2011
Externally publishedYes


  • 2D sheets
  • cyclic dipeptide
  • molecular chains
  • molecular layers
  • self-assembly


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