Spontaneous resolution of extreme thrombocytosis in 2 children

Shraga Aviner, Ehud Even-Or, Hannah Tamary

Research output: Contribution to journalArticlepeer-review


Essential thrombocytosis (ET) is rare in children, sometimes difficult to be distinguished from secondary thrombocytosis. This report concerns 2 children with extreme thrombocytosis of 4100 × 10 9/L and 1644 × 10 9/L with partial and complete remission at 3 months and 4 years from diagnosis, with a follow-up of 4 and 17 years, respectively, with no cytoreduction therapy. Diagnosis of ET was suggested according to accepted criteria. However, spontaneous remission of the thrombocytosis argues for the diagnosis of secondary thrombocytosis. These patients highlight the complexity of distinguishing childhood ET from secondary thrombocytosis and the need for cautious personalized decision on cytoreduction therapy.

Original languageEnglish
Pages (from-to)372-377
Number of pages6
JournalPediatric Hematology and Oncology
Issue number4
StatePublished - May 2012


  • Cytoreduction
  • Essential thrombocytosis
  • Platelet count
  • Platelets
  • Secondary thrombocytosis


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