Spontaneous remission of childhood acute marrow fibrosis and megakaryoblastic leukemia

Ronit Elhasid*, Tali Tohami, Nivin Moustafa-Hawash, Jonathan Ben-Ezra, Shai Izraeli, Dror Sayar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Spontaneous remission in 2 children with myelofibrosis, one with megakaryocytic acute myeloblastic leukemia and t(1;22) (with recurrence later) and one with Down syndrome and GATA1 mutation (permanent), are described. One had sepsis and was treated with antibiotics and blood products, whereas the other received only blood products. Remission was spontaneous, without chemotherapy treatment. Possible explanations for these outcomes include immunologic response to sepsis by a leukemia-specific T-cell response or the release of various cytokines, such as tumor necrosis factor and interleukin-2, during infections. Natural killer and cytotoxic T cells transfused with blood products might have also triggered an immune response.

Original languageEnglish
Pages (from-to)565-568
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume34
Issue number7
DOIs
StatePublished - Oct 2012

Keywords

  • Down syndrome
  • GATA1 mutation
  • acute megakaryocytic leukemia
  • myelofibrosis
  • spontaneous remission
  • t(1;22) translocation

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