TY - JOUR
T1 - Spontaneous remission of childhood acute marrow fibrosis and megakaryoblastic leukemia
AU - Elhasid, Ronit
AU - Tohami, Tali
AU - Moustafa-Hawash, Nivin
AU - Ben-Ezra, Jonathan
AU - Izraeli, Shai
AU - Sayar, Dror
PY - 2012/10
Y1 - 2012/10
N2 - Spontaneous remission in 2 children with myelofibrosis, one with megakaryocytic acute myeloblastic leukemia and t(1;22) (with recurrence later) and one with Down syndrome and GATA1 mutation (permanent), are described. One had sepsis and was treated with antibiotics and blood products, whereas the other received only blood products. Remission was spontaneous, without chemotherapy treatment. Possible explanations for these outcomes include immunologic response to sepsis by a leukemia-specific T-cell response or the release of various cytokines, such as tumor necrosis factor and interleukin-2, during infections. Natural killer and cytotoxic T cells transfused with blood products might have also triggered an immune response.
AB - Spontaneous remission in 2 children with myelofibrosis, one with megakaryocytic acute myeloblastic leukemia and t(1;22) (with recurrence later) and one with Down syndrome and GATA1 mutation (permanent), are described. One had sepsis and was treated with antibiotics and blood products, whereas the other received only blood products. Remission was spontaneous, without chemotherapy treatment. Possible explanations for these outcomes include immunologic response to sepsis by a leukemia-specific T-cell response or the release of various cytokines, such as tumor necrosis factor and interleukin-2, during infections. Natural killer and cytotoxic T cells transfused with blood products might have also triggered an immune response.
KW - Down syndrome
KW - GATA1 mutation
KW - acute megakaryocytic leukemia
KW - myelofibrosis
KW - spontaneous remission
KW - t(1;22) translocation
UR - http://www.scopus.com/inward/record.url?scp=84866938173&partnerID=8YFLogxK
U2 - 10.1097/MPH.0b013e318257a172
DO - 10.1097/MPH.0b013e318257a172
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C2 - 22627572
AN - SCOPUS:84866938173
SN - 1077-4114
VL - 34
SP - 565
EP - 568
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
IS - 7
ER -