Spontaneous bilateral femoral fractures after high-dose zoledronic acid

Yaron S. Brin*, Ezequiel Palmanovich, Ziv Heler, Benyamin Josef Kish, Meir Nyska, Henry Bismuth, Ryan Coughlin, Tanya Zehavi, Pnina Rotman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The authors report a case of spontaneous bilateral diaphyseal femoral fractures believed to be caused by oversuppression of bone remodeling as a result of long-term, high-dose treatment with bisphosphonate. The patient reported pain in both thighs before the fractures. Typical pathologic changes appeared on both femoral radiograph and bone scan before the fractures. Several hours after admission to the emergency department of the authors' institution, the patient underwent closed re-duction and internal fixation with intramedullary nails for the bilateral femoral diaphyseal fractures. Treatment with zoledronic acid was immediately discontinued. In recent years, low-energy femoral diaphyseal fractures in patients undergoing long-term bisphosphonate treatment have been reported. It is believed that the prolonged treatment causes long-term suppression of bone remodeling and accumulation of microdamage. It is important to observe patients who are undergoing bisphosphonate treatment carefully. In this case study, the authors report the patient's unique medical history.

Original languageEnglish
Pages (from-to)e1051-e1054
Issue number11
StatePublished - Nov 2015


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