TY - JOUR
T1 - Spontaneous abortion in patients with insulin-dependent diabetes mellitus
T2 - The effect of preconceptional diabetic control
AU - Dicker, Dov
AU - Feldberg, Dov
AU - Samuel, Nurit
AU - Yeshaya, Arie
AU - Karp, Moshe
AU - Goldman, Jack A.
PY - 1988
Y1 - 1988
N2 - Fifty-nine of 94 pregnant women with juvenile-onset insulin-dependent diabetes who attended a preconceptional clinic were periodically examined by a diabetologic team. Glycemic control was obtained by intensified insulin therapy and monitored by blood glucose self-monitoring. These women were compared with the 35 pregnant women who did not receive preconceptual glycemic control. The initial glucose and maternal hemoglobin A1 values of the latter group experiencing spontaneous abortions were significantly higher (p < 0.001) when compared with women receiving preconceptional diabetologic counseling whose pregnancies continued beyond 22 weeks' gestation. The frequency of spontaneous abortions among patients not seen before pregnancy was significantly higher (p < 0.001), in contrast to attending women, whose rate represented the normal rate in the general population. We confirm the evidence accumulated in the recent literature that poor metabolic control around conception and in the early weeks of pregnancy may be the determining factor favoring abortion.
AB - Fifty-nine of 94 pregnant women with juvenile-onset insulin-dependent diabetes who attended a preconceptional clinic were periodically examined by a diabetologic team. Glycemic control was obtained by intensified insulin therapy and monitored by blood glucose self-monitoring. These women were compared with the 35 pregnant women who did not receive preconceptual glycemic control. The initial glucose and maternal hemoglobin A1 values of the latter group experiencing spontaneous abortions were significantly higher (p < 0.001) when compared with women receiving preconceptional diabetologic counseling whose pregnancies continued beyond 22 weeks' gestation. The frequency of spontaneous abortions among patients not seen before pregnancy was significantly higher (p < 0.001), in contrast to attending women, whose rate represented the normal rate in the general population. We confirm the evidence accumulated in the recent literature that poor metabolic control around conception and in the early weeks of pregnancy may be the determining factor favoring abortion.
KW - Spontaneous abortion
KW - diabetes in pregnancy
KW - early fetal loss
KW - preconceptional diabetes control
KW - pregnancy planning in diabetes
UR - http://www.scopus.com/inward/record.url?scp=0023884725&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(88)90245-1
DO - 10.1016/0002-9378(88)90245-1
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AN - SCOPUS:0023884725
SN - 0002-9378
VL - 158
SP - 1161
EP - 1164
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 5
ER -
