Splenocytes incorporated with exogenous gangliosides induce a mixed lymphocyte reaction in autologous lymphocytes

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Abstract

SWR splenocytes incorporated with mixed gangliosides triggered an efficient mixed lymphocyte reaction in autologous thymus lymphocytes. The potency of the ganglioside-incorporated splenocytes as stimulators in the autologous system was eight to ninefold greater than background effect of untreated splenocytes. The induced mixed lymphocyte reaction was not due to free gangliosides in culture medium and occurred only if the gangliosides were incorporated into the triggering splenocytes, but not into the responding thymocytes. The mixed lymphocyte reaction generated by gangliosides incorporation in the autologous system is similar to that reaction in the allogeneic system with regard to the time course of [3H]thymidine incorporation.

Original languageEnglish
Pages (from-to)196-201
Number of pages6
JournalCellular Immunology
Volume49
Issue number1
DOIs
StatePublished - Jan 1980
Externally publishedYes

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