Spinal Canal Involvement in Peripheral Neuroblastic Tumors

Shifra Ash, Stefania Sorrentino, Kathelijne Kraal, Bruno De Bernardi*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Approximately 15% of children with peripheral neuroblastic tumors (PNTs) present with spinal canal involvement (SCI) by the tumor, and half of them develop important related symptoms. Symptomatic SCI requires prompt treatment: chemotherapy, neurosurgical intervention and radiation therapy may all be effective, but there is no consent on which should be given first in the different clinical presentations. The literature regarding PNT with SCI does not provide convincing guidelines, thus encouraging the establishment of a specific International Registry to provide data that could lead to the definition of a suitable therapeutic and follow-up algorithm.

Original languageEnglish
Title of host publicationNeuroblastoma
Subtitle of host publicationClinical and Surgical Management
PublisherSpringer International Publishing
Number of pages17
ISBN (Electronic)9783030183967
ISBN (Print)9783030183950
StatePublished - 1 Jan 2019


  • Chemotherapy
  • Epidural compression
  • Imaging of SCI
  • Laminectomy and laminotomy
  • Late sequelae
  • Multidisciplinary follow-up
  • Multidisciplinary therapeutic approach
  • Neuroblastoma
  • Peripheral neuroblastic tumors
  • Radiation therapy
  • SCI at birth and in the neonate
  • Spinal canal involvement (SCI)


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