TY - JOUR
T1 - Spinal anaesthesia induced by intrathecal magnesium sulphate
T2 - An experimental study in a rat model
AU - Bahar, M.
AU - Chanimov, M.
AU - Grinspun, E.
AU - Koifman, I.
AU - Cohen, M. L.
PY - 1996
Y1 - 1996
N2 - We have demonstrated in a rat model that the intrathecal injection of 0.02 ml of 6.3% magnesium sulphate, a concentration iso-osmolar with rat plasma, will produce a state of spinal anaesthesia and general sedation, lasting approximately 1h. These effects reversed completely after 6h, without evidence of neurotoxicity, immediately or during the period 1 week following the injection. The accompanying changes in haemodynamic and respiratory functions were minimal throughout the period of anaesthesia and compared favourably with those induced by an intrathecal bolus of 0.04 ml of 2% lignocaine.
AB - We have demonstrated in a rat model that the intrathecal injection of 0.02 ml of 6.3% magnesium sulphate, a concentration iso-osmolar with rat plasma, will produce a state of spinal anaesthesia and general sedation, lasting approximately 1h. These effects reversed completely after 6h, without evidence of neurotoxicity, immediately or during the period 1 week following the injection. The accompanying changes in haemodynamic and respiratory functions were minimal throughout the period of anaesthesia and compared favourably with those induced by an intrathecal bolus of 0.04 ml of 2% lignocaine.
KW - Anaesthetic techniques regional; intrathecal
KW - Pharmacology; magnesium sulphate, lignocaine
UR - http://www.scopus.com/inward/record.url?scp=0029949733&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2044.1996.tb07843.x
DO - 10.1111/j.1365-2044.1996.tb07843.x
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AN - SCOPUS:0029949733
SN - 0003-2409
VL - 51
SP - 627
EP - 633
JO - Anaesthesia
JF - Anaesthesia
IS - 7
ER -