We have demonstrated in a rat model that the intrathecal injection of 0.02 ml of 6.3% magnesium sulphate, a concentration iso-osmolar with rat plasma, will produce a state of spinal anaesthesia and general sedation, lasting approximately 1h. These effects reversed completely after 6h, without evidence of neurotoxicity, immediately or during the period 1 week following the injection. The accompanying changes in haemodynamic and respiratory functions were minimal throughout the period of anaesthesia and compared favourably with those induced by an intrathecal bolus of 0.04 ml of 2% lignocaine.
|Number of pages||7|
|State||Published - 1996|
- Anaesthetic techniques regional; intrathecal
- Pharmacology; magnesium sulphate, lignocaine