TY - JOUR
T1 - SPIKE
T2 - A database of highly curated human signaling pathways
AU - Paz, Arnon
AU - Brownstein, Zippora
AU - Ber, Yaara
AU - Bialik, Shani
AU - David, Eyal
AU - Sagir, Dorit
AU - Ulitsky, Igor
AU - Elkon, Ran
AU - Kimchi, Adi
AU - Avraham, Karen B.
AU - Shiloh, Yosef
AU - Shamir, Ron
N1 - Funding Information:
TRIREME project, EC Seventh Framework Programme (grants HEALTH-F4-2009-223575 to R.S. and Y.S.); HEALTH-F4-2007-200767 for the APO-SYS project (to R.S. and A.K.); Converging Technologies Program of the Israel Science Foundation (grant 1767.07 to R.S. and Y.S.); A-T Medical Research Foundation (to Y.S.); the Israel Cancer Research Fund (to Y.S.); The Dr Miriam and Sheldon G. Adelson Medical Research Foundation (to Y.S.); Israel Science Foundation (grant 1486/07 to K.B.A.); NIH/NIDCD (grant R01 DC005641 to K.B.A.); European Commission FP6 Eumodic 037188 (to K.B.A.); Center of Excellence grant from the Flight Attendant Medical Research Institute (FAMRI, to A.K.). A.K. is the incumbent of Helena Rubinstein Chair of Cancer Research. Y.S. is a Research Professor of the Israel Cancer Research Fund. R.S. is the incumbent of the Raymond and Beverly Sackler Chair in Bioinformatics; Edmond J. Safra Bioinformatics program at Tel-Aviv University, fellowship (A.P. and I.U.). Funding for open access charge: TRIREME project, EC Seventh Framework Programme (grants HEALTH-F4-2009-223575 to R.S. and Y.S.).
PY - 2011/1
Y1 - 2011/1
N2 - The rapid accumulation of knowledge on biological signaling pathways and their regulatory mechanisms has highlighted the need for specific repositories that can store, organize and allow retrieval of pathway information in a way that will be useful for the research community. SPIKE (Signaling Pathways Integrated Knowledge Engine; http:// www.cs.tau.ac.il/spike/) is a database for achieving this goal, containing highly curated interactions for particular human pathways, along with literature-referenced information on the nature of each interaction. To make database population and pathway comprehension straightforward, a simple yet informative data model is used, and pathways are laid out as maps that reflect the curator's understanding and make the utilization of the pathways easy. The database currently focuses primarily on pathways describing DNA damage response, cell cycle, programmed cell death and hearing related pathways. Pathways are regularly updated, and additional pathways are gradually added. The complete database and the individual maps are freely exportable in several formats. The database is accompanied by a stand-alone software tool for analysis and dynamic visualization of pathways.
AB - The rapid accumulation of knowledge on biological signaling pathways and their regulatory mechanisms has highlighted the need for specific repositories that can store, organize and allow retrieval of pathway information in a way that will be useful for the research community. SPIKE (Signaling Pathways Integrated Knowledge Engine; http:// www.cs.tau.ac.il/spike/) is a database for achieving this goal, containing highly curated interactions for particular human pathways, along with literature-referenced information on the nature of each interaction. To make database population and pathway comprehension straightforward, a simple yet informative data model is used, and pathways are laid out as maps that reflect the curator's understanding and make the utilization of the pathways easy. The database currently focuses primarily on pathways describing DNA damage response, cell cycle, programmed cell death and hearing related pathways. Pathways are regularly updated, and additional pathways are gradually added. The complete database and the individual maps are freely exportable in several formats. The database is accompanied by a stand-alone software tool for analysis and dynamic visualization of pathways.
UR - http://www.scopus.com/inward/record.url?scp=78651290281&partnerID=8YFLogxK
U2 - 10.1093/nar/gkq1167
DO - 10.1093/nar/gkq1167
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AN - SCOPUS:78651290281
SN - 0305-1048
VL - 39
SP - D793-D799
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - SUPPL. 1
ER -