Spermiogenesis defects in human: Detection of transition proteins in semen from some infertile men

S. Becker, Y. Soffer, L. M. Lewin, L. Yogev, L. Shochat, R. Golan

Research output: Contribution to journalArticlepeer-review

Abstract

Semen samples from 60 infertile men were examined by flow cytometry following propidium iodide staining. Of these, 23 samples contained young haploid cells. Transition proteins (TP1 and/or TP2) were detected in 12 of these, using immunohistochemical staining. The presence of TPs in spermatids in semen indicates inhibition in the differentiation pathway from round spermatids to spermatozoa. Cells of this type were found in semen from patients with nonobstructive azoospermia, severe to extreme cases of oligozoospermia, asthenozoospermia and teratozoospermia.

Original languageEnglish
Pages (from-to)203-208
Number of pages6
JournalAndrologia
Volume40
Issue number4
DOIs
StatePublished - Aug 2008

Keywords

  • Flow cytometry
  • Fluorescence
  • Male infertility
  • Spermatid transition proteins
  • Spermiogenesis

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