Spermiogenesis defects in human: Detection of transition proteins in semen from some infertile men

S. Becker; Y. Soffer; L. M. Lewin; L. Yogev; L. Shochat; R. Golan

doi:10.1111/j.1439-0272.2008.00844.x

Spermiogenesis defects in human: Detection of transition proteins in semen from some infertile men

S. Becker, Y. Soffer, L. M. Lewin, L. Yogev, L. Shochat, R. Golan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Semen samples from 60 infertile men were examined by flow cytometry following propidium iodide staining. Of these, 23 samples contained young haploid cells. Transition proteins (TP1 and/or TP2) were detected in 12 of these, using immunohistochemical staining. The presence of TPs in spermatids in semen indicates inhibition in the differentiation pathway from round spermatids to spermatozoa. Cells of this type were found in semen from patients with nonobstructive azoospermia, severe to extreme cases of oligozoospermia, asthenozoospermia and teratozoospermia.

Original language	English
Pages (from-to)	203-208
Number of pages	6
Journal	Andrologia
Volume	40
Issue number	4
DOIs	https://doi.org/10.1111/j.1439-0272.2008.00844.x
State	Published - Aug 2008

Keywords

Flow cytometry
Fluorescence
Male infertility
Spermatid transition proteins
Spermiogenesis

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abstract = "Semen samples from 60 infertile men were examined by flow cytometry following propidium iodide staining. Of these, 23 samples contained young haploid cells. Transition proteins (TP1 and/or TP2) were detected in 12 of these, using immunohistochemical staining. The presence of TPs in spermatids in semen indicates inhibition in the differentiation pathway from round spermatids to spermatozoa. Cells of this type were found in semen from patients with nonobstructive azoospermia, severe to extreme cases of oligozoospermia, asthenozoospermia and teratozoospermia.",

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AU - Shochat, L.

AU - Golan, R.

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Spermiogenesis defects in human: Detection of transition proteins in semen from some infertile men

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