Sperm motility is a major determinant of pregnancy outcome following intrauterine insemination

Adrian Shulman*, Roni Hauser, Shlomo Lipitz, Yair Frenkel, Jehoshua Dor, David Bider, Shlomo Mashiach, Lea Yogev, Haym Yavetz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Purpose: Our purpose was to assess whether one or more sperm parameters have predictive value for the outcome of intrauterine insemination treatment. Methods: Infertile couples whose normoovulatory and normomechanical female partners underwent superovulation and intrauterine insemination were investigated. The semen profile of the male partner was discounted. In 160 couples, 544 cycles were obtained, resulting in 59 ongoing pregnancies (10.84%/cycle, 36.87%/patient). Results: The only parameter found to be significantly correlated with a positive outcome was the degree of sperm motility following preparation for intrauterine insemination. Close to half (47.5%) of the couples with a very good or an excellent degree of sperm motility conceived, whereas only 8.3% of those patients who had poor or fair sperm motility conceived. None of the semen characteristics, such as volume, count, percentage motility, or percentage normal morphology, were found to correlate with cycle outcome. Although there was a progressive increase in the pregnancy rate with an increase in the total number of motile sperm inseminated, it did not reach significance. Seventy percent of the pregnancies were achieved within a maximum of three treatment cycles. The spermatogram is not accurate enough as a prognostic factor for treatment outcome. Conclusions: The degree of sperm motility, after appropriate preparation for intrauterine insemination, is the only parameter to be correlated with treatment outcome. For couples with a normal female partner, we suggest a maximum of three treatment cycles of induction of ovulation and intrauterine insemination, whenever good progressive motile sperm is obtained after suitable preparation. For cases with poor sperm progression, we suggest appropriate couple counseling and that an alternative assisted reproduction procedure be taken into consideration.

Original languageEnglish
Pages (from-to)381-385
Number of pages5
JournalJournal of Assisted Reproduction and Genetics
Issue number6
StatePublished - 1998
Externally publishedYes


  • Conception
  • Intrauterine insemination
  • Pregnancy
  • Sperm motility


Dive into the research topics of 'Sperm motility is a major determinant of pregnancy outcome following intrauterine insemination'. Together they form a unique fingerprint.

Cite this