SPECT/CT-plethysmography - Non-invasive quantitation of bone and soft tissue blood flow

Lior Dayan, Zohar Keidar, Ora Israel, Victor Milloul, Johnathan Sachs, Giris Jacob*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Preserved blood flow to bone and soft tissue is essential for their normal function. To date only numerous methods are suitable for direct bone blood flow (BBF) measurement. Here, we introduce a novel quantitative method for bone and soft tissue blood flow (BBF and SBF, respectively) measurement. It involves a combination of SPECT/CT imaging for blood pool localization in a specific region of interest ("soft" and "hard" tissues composing a limb) with veno-occlusive plethysmography. Using it, we measured BBF and SBF in the four limbs of 10 healthy subjects. At steady state blood flow measurements in the four limbs were similar, ranging between 5.5 - 6.5 and 1.87-2.48 ml per 100 ml of tissue per minute for BBF and SBF, respectively. Our results are comparable to those in the literature. We concluded that SPECT/CT- plethysmography appears to be a readily available and easy to use method to measure BBF and SBF, and can be added to the armamentarium of methods for BBF measurements.

Original languageEnglish
Article number36
JournalJournal of Orthopaedic Surgery and Research
Issue number1
StatePublished - 2008
Externally publishedYes


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