Specific stimulation of RNA synthesis by methionine in several strains of Escherichia coli

Eliora Z. Ron, Bernard D. Davis

Research output: Contribution to journalArticlepeer-review

Abstract

The addition of methionine to a growing culture of certain strains of Escherichia coli causes a preferential stimulation of RNA synthesis. In the new steady state the RNA/protein ratio is increased 25% or more, with little change in growth rate. The excess RNA is found largely in ribosomes and appears to be normally methylated. The rate of restoration of the normal RNA/protein ratio after removal of methionine suggests that the extra ribosomes, though not contributing to the rate of protein synthesis, are functional. Possible mechanisms to explain this variation in the control of RNA synthesis are discussed.

Original languageEnglish
Pages (from-to)13-27
Number of pages15
JournalJournal of Molecular Biology
Volume21
Issue number1
DOIs
StatePublished - 28 Oct 1966
Externally publishedYes

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