TY - JOUR
T1 - Specific protein biomarker patterns for Alzheimer’s disease
T2 - improved diagnostics in progress
AU - Gozes, Illana
N1 - Publisher Copyright:
© 2017, European Association for Predictive, Preventive and Personalised Medicine (EPMA).
PY - 2017/9/4
Y1 - 2017/9/4
N2 - This short review looks at Alzheimer’s disease (AD) diagnosis through my own point of view, going from imaging through cerebrospinal fluid to blood proteins. Over the last couple of years, we have published two papers targeted at Alzheimer’s diagnosis. In one paper, we took an approach of selecting a specific target, namely, activity-dependent neuroprotective protein (ADNP), and our results tightened the association of ADNP blood expression with intelligence. In another paper, we took an unbiased approach of analysis of all genes expressed in lymphoblastoid cells lines and discovered changes in expression of the regulator of G-protein signaling 2 (RGS2) as a potential AD predictor. This review will assess our data in comparison to selected independent studies focusing on blood protein biomarkers as well as assessing saliva and urine samples with potential predictive value for AD. Furthermore, the review will provide directions for a combination of innovative markers, stratifying the population toward disease prevention and personalized medicine.
AB - This short review looks at Alzheimer’s disease (AD) diagnosis through my own point of view, going from imaging through cerebrospinal fluid to blood proteins. Over the last couple of years, we have published two papers targeted at Alzheimer’s diagnosis. In one paper, we took an approach of selecting a specific target, namely, activity-dependent neuroprotective protein (ADNP), and our results tightened the association of ADNP blood expression with intelligence. In another paper, we took an unbiased approach of analysis of all genes expressed in lymphoblastoid cells lines and discovered changes in expression of the regulator of G-protein signaling 2 (RGS2) as a potential AD predictor. This review will assess our data in comparison to selected independent studies focusing on blood protein biomarkers as well as assessing saliva and urine samples with potential predictive value for AD. Furthermore, the review will provide directions for a combination of innovative markers, stratifying the population toward disease prevention and personalized medicine.
KW - Alzheimer’s disease (AD)
KW - Personalized medicine
KW - Predictive
KW - Preventive
UR - http://www.scopus.com/inward/record.url?scp=85029644697&partnerID=8YFLogxK
U2 - 10.1007/s13167-017-0110-x
DO - 10.1007/s13167-017-0110-x
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C2 - 29021836
AN - SCOPUS:85029644697
SN - 1878-5077
VL - 8
SP - 255
EP - 259
JO - EPMA Journal
JF - EPMA Journal
IS - 3
ER -
