TY - JOUR
T1 - Specific proliferative responses following the induction of experimental SLE in mice
AU - Mendlovic, S.
AU - Levy, Y.
AU - Mozes, E.
N1 - Funding Information:
This work was supported in part by a research grant from the Crown Endowment Fund for immunological research at The Weizmann Institute of Science and in part by the Basic Research Foundation administered by the Israel Academy of Sciences and Humanities.
PY - 1991/1
Y1 - 1991/1
N2 - We have previously reported the induction of experimental systematic lupus erythematosus (SLE) in mice by immunization with a human monoclonal antibody that expresses a common anti-DNA idiotype (16/6 Id). Following immunization, antibodies directed against various nuclear autoantigens could be detected in the sera of the mice. In the present study, we investigated the proliferative responses of lymph node cells to one particular autoantigen (DNA) following the induction of experimental SLE. Cells reactive with ssDNA could be detected following immunization of BALB/c mice with the 16/6 Id. The appearance of these DNA-reactive cells succeeded the appearance of 16/6 Id-specific cells. The activation of this subset of autoreactive cells could be achieved only by the immunization of the mice with the 16/6 Id, but not by their immunization with DNA, thus suggesting that the induction of experimental SLE is associated with the alteration of the low responsive potential of the mice to DNA.
AB - We have previously reported the induction of experimental systematic lupus erythematosus (SLE) in mice by immunization with a human monoclonal antibody that expresses a common anti-DNA idiotype (16/6 Id). Following immunization, antibodies directed against various nuclear autoantigens could be detected in the sera of the mice. In the present study, we investigated the proliferative responses of lymph node cells to one particular autoantigen (DNA) following the induction of experimental SLE. Cells reactive with ssDNA could be detected following immunization of BALB/c mice with the 16/6 Id. The appearance of these DNA-reactive cells succeeded the appearance of 16/6 Id-specific cells. The activation of this subset of autoreactive cells could be achieved only by the immunization of the mice with the 16/6 Id, but not by their immunization with DNA, thus suggesting that the induction of experimental SLE is associated with the alteration of the low responsive potential of the mice to DNA.
KW - 16/6 Idiotype
KW - DNA-specific response
KW - Systemic lupus crythematosus
UR - http://www.scopus.com/inward/record.url?scp=0025962366&partnerID=8YFLogxK
U2 - 10.1016/0165-2478(91)90247-8
DO - 10.1016/0165-2478(91)90247-8
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C2 - 2019423
AN - SCOPUS:0025962366
SN - 0165-2478
VL - 27
SP - 69
EP - 73
JO - Immunology Letters
JF - Immunology Letters
IS - 1
ER -