Specific and efficient adsorption of phosphorothioated DNA on Au-based surfaces and electrodes

Jamal Ghabboun, Mukhles Sowwan, Hezy Cohen, Tatiana Molotsky, Natalia Borovok, Benjamin Dwir, Eli Kapon, Alexander Kotlyar*, Danny Porath

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Efficient attachment of DNA to metal surfaces or electrodes is essential for charge-transport measurements, scanning tunneling microscopy, and for devices and sensors. To optimize DNA deposition on Au-based surfaces and electrodes, we synthesized DNA with phosphorothioate (PT) groups attached to the G strand of poly(deoxyguanine)-poly(deoxycytosine) [poly(dG)-poly(dC)]. This procedure strongly improves the DNA anchoring to Au-based surfaces by sulfur-gold interaction. Much higher molecular surface density on Au substrates was observed for PT poly(dG)-poly(dC) compared to "bare" molecules. Deposition of PT poly(dG)-poly(dC) on Au-based electrodes, followed by thorough washing, showed that they specifically attach to the electrodes and are not spread on the surrounding Si O2 surface.

Original languageEnglish
Article number173101
JournalApplied Physics Letters
Issue number17
StatePublished - 2007


FundersFunder number
French Ministry of External Affairs
Israeli-Palestinian Science Organization
Lazard Frères Foundation
European CommissionIST-2001-38951, FP6-029192


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