@article{a538f8445e324135b394c203cc11d9ba,
title = "Specific and efficient adsorption of phosphorothioated DNA on Au-based surfaces and electrodes",
abstract = "Efficient attachment of DNA to metal surfaces or electrodes is essential for charge-transport measurements, scanning tunneling microscopy, and for devices and sensors. To optimize DNA deposition on Au-based surfaces and electrodes, we synthesized DNA with phosphorothioate (PT) groups attached to the G strand of poly(deoxyguanine)-poly(deoxycytosine) [poly(dG)-poly(dC)]. This procedure strongly improves the DNA anchoring to Au-based surfaces by sulfur-gold interaction. Much higher molecular surface density on Au substrates was observed for PT poly(dG)-poly(dC) compared to {"}bare{"} molecules. Deposition of PT poly(dG)-poly(dC) on Au-based electrodes, followed by thorough washing, showed that they specifically attach to the electrodes and are not spread on the surrounding Si O2 surface.",
author = "Jamal Ghabboun and Mukhles Sowwan and Hezy Cohen and Tatiana Molotsky and Natalia Borovok and Benjamin Dwir and Eli Kapon and Alexander Kotlyar and Danny Porath",
note = "Funding Information: We thank Igor Brodsky and Moti Zimmermann for technical assistance. We acknowledge financial support from the European Union through IST Future and Emerging Technologies Projects: Nos. IST-2001-38951 (“DNA-Based Nanowires”) and FP6-029192 (“DNA-Based Nanodevices”) and of the French Ministry of External Affairs, the Lazard Fr{\`e}res Foundation and the Israeli-Palestinian Science Organization(IPSO).",
year = "2007",
doi = "10.1063/1.2800383",
language = "אנגלית",
volume = "91",
journal = "Applied Physics Letters",
issn = "0003-6951",
publisher = "American Institute of Physics",
number = "17",
}