Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum

Parthiv Haldipur; Kimberly A. Aldinger; Silvia Bernardo; Mei Deng; Andrew E. Timms; Lynne M. Overman; Conrad Winter; Steven N. Lisgo; Ferechte Razavi; Evelina Silvestri; Lucia Manganaro; Homa Adle-Biasette; Fabien Guilmiot; Rosa Russo; Debora Kidron; Patrick R. Hof; Dianne Gerrelli; Susan J. Lindsay; William B. Dobyns; Ian A. Glass; Paula Alexandre; Kathleen J. Millen

doi:10.1126/science.aax7526

Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum

Parthiv Haldipur, Kimberly A. Aldinger, Silvia Bernardo, Mei Deng, Andrew E. Timms, Lynne M. Overman, Conrad Winter, Steven N. Lisgo, Ferechte Razavi, Evelina Silvestri, Lucia Manganaro, Homa Adle-Biasette, Fabien Guilmiot, Rosa Russo, Debora Kidron, Patrick R. Hof, Dianne Gerrelli, Susan J. Lindsay, William B. Dobyns, Ian A. GlassPaula Alexandre, Kathleen J. Millen^*

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

We present histological and molecular analyses of the developing human cerebellum from 30 days after conception to 9 months after birth. Differences in developmental patterns between humans and mice include spatiotemporal expansion of both ventricular and rhombic lip primary progenitor zones to include subventricular zones containing basal progenitors. The human rhombic lip persists longer through cerebellar development than in the mouse and undergoes morphological changes to form a progenitor pool in the posterior lobule, which is not seen in other organisms, not even in the nonhuman primate the macaque. Disruptions in human rhombic lip development are associated with posterior cerebellar vermis hypoplasia and Dandy-Walker malformation. The presence of these species-specific neural progenitor populations refines our insight into human cerebellar developmental disorders.

Original language	English
Pages (from-to)	454-460
Number of pages	7
Journal	Science
Volume	366
Issue number	6464
DOIs	https://doi.org/10.1126/science.aax7526
State	Published - 25 Oct 2019

Funding

Funders	Funder number
National Institute of Neurological Disorders and Stroke	R01NS095733

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Haldipur, P., Aldinger, K. A., Bernardo, S., Deng, M., Timms, A. E., Overman, L. M., Winter, C., Lisgo, S. N., Razavi, F., Silvestri, E., Manganaro, L., Adle-Biasette, H., Guilmiot, F., Russo, R., Kidron, D., Hof, P. R., Gerrelli, D., Lindsay, S. J., Dobyns, W. B., ... Millen, K. J. (2019). Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum. Science, 366(6464), 454-460. https://doi.org/10.1126/science.aax7526

@article{eb082a272d244f99959b2c9d987e76f0,

title = "Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum",

abstract = "We present histological and molecular analyses of the developing human cerebellum from 30 days after conception to 9 months after birth. Differences in developmental patterns between humans and mice include spatiotemporal expansion of both ventricular and rhombic lip primary progenitor zones to include subventricular zones containing basal progenitors. The human rhombic lip persists longer through cerebellar development than in the mouse and undergoes morphological changes to form a progenitor pool in the posterior lobule, which is not seen in other organisms, not even in the nonhuman primate the macaque. Disruptions in human rhombic lip development are associated with posterior cerebellar vermis hypoplasia and Dandy-Walker malformation. The presence of these species-specific neural progenitor populations refines our insight into human cerebellar developmental disorders.",

author = "Parthiv Haldipur and Aldinger, {Kimberly A.} and Silvia Bernardo and Mei Deng and Timms, {Andrew E.} and Overman, {Lynne M.} and Conrad Winter and Lisgo, {Steven N.} and Ferechte Razavi and Evelina Silvestri and Lucia Manganaro and Homa Adle-Biasette and Fabien Guilmiot and Rosa Russo and Debora Kidron and Hof, {Patrick R.} and Dianne Gerrelli and Lindsay, {Susan J.} and Dobyns, {William B.} and Glass, {Ian A.} and Paula Alexandre and Millen, {Kathleen J.}",

year = "2019",

month = oct,

day = "25",

doi = "10.1126/science.aax7526",

language = "אנגלית",

volume = "366",

pages = "454--460",

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Haldipur, P, Aldinger, KA, Bernardo, S, Deng, M, Timms, AE, Overman, LM, Winter, C, Lisgo, SN, Razavi, F, Silvestri, E, Manganaro, L, Adle-Biasette, H, Guilmiot, F, Russo, R, Kidron, D, Hof, PR, Gerrelli, D, Lindsay, SJ, Dobyns, WB, Glass, IA, Alexandre, P & Millen, KJ 2019, 'Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum', Science, vol. 366, no. 6464, pp. 454-460. https://doi.org/10.1126/science.aax7526

TY - JOUR

T1 - Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum

AU - Haldipur, Parthiv

AU - Aldinger, Kimberly A.

AU - Bernardo, Silvia

AU - Deng, Mei

AU - Timms, Andrew E.

AU - Overman, Lynne M.

AU - Winter, Conrad

AU - Lisgo, Steven N.

AU - Razavi, Ferechte

AU - Silvestri, Evelina

AU - Manganaro, Lucia

AU - Adle-Biasette, Homa

AU - Guilmiot, Fabien

AU - Russo, Rosa

AU - Kidron, Debora

AU - Hof, Patrick R.

AU - Gerrelli, Dianne

AU - Lindsay, Susan J.

AU - Dobyns, William B.

AU - Glass, Ian A.

AU - Alexandre, Paula

AU - Millen, Kathleen J.

PY - 2019/10/25

Y1 - 2019/10/25

N2 - We present histological and molecular analyses of the developing human cerebellum from 30 days after conception to 9 months after birth. Differences in developmental patterns between humans and mice include spatiotemporal expansion of both ventricular and rhombic lip primary progenitor zones to include subventricular zones containing basal progenitors. The human rhombic lip persists longer through cerebellar development than in the mouse and undergoes morphological changes to form a progenitor pool in the posterior lobule, which is not seen in other organisms, not even in the nonhuman primate the macaque. Disruptions in human rhombic lip development are associated with posterior cerebellar vermis hypoplasia and Dandy-Walker malformation. The presence of these species-specific neural progenitor populations refines our insight into human cerebellar developmental disorders.

AB - We present histological and molecular analyses of the developing human cerebellum from 30 days after conception to 9 months after birth. Differences in developmental patterns between humans and mice include spatiotemporal expansion of both ventricular and rhombic lip primary progenitor zones to include subventricular zones containing basal progenitors. The human rhombic lip persists longer through cerebellar development than in the mouse and undergoes morphological changes to form a progenitor pool in the posterior lobule, which is not seen in other organisms, not even in the nonhuman primate the macaque. Disruptions in human rhombic lip development are associated with posterior cerebellar vermis hypoplasia and Dandy-Walker malformation. The presence of these species-specific neural progenitor populations refines our insight into human cerebellar developmental disorders.

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Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum

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