Spatial interactions in amblyopia: Effects of stimulus parameters and amblyopia type

U. Polat, Y. Bonneh, T. Ma-Naim, M. Belkin, D. Sagi

Research output: Contribution to journalArticlepeer-review

Abstract

Adults with amblyopia were recently shown to perform abnormally in tasks requiring integration of local features into global percepts. Moreover, spatial interactions in amblyopic patients, though often found to be abnormal, showed marked variability. Here we measured collinear lateral interactions using Gabor patches in a large number of amblyopic (N = 75) and normal subjects (N = 25), testing four spatial frequencies (1.5, 3, 6, 9 cpd). We used the lateral masking paradigm, in which the contrast-detection threshold is measured in the presence of high-contrast flankers at different distances from a central target. Whereas in normal subjects spatial interaction patterns were evident across all spatial frequencies, amblyopic subjects showed abnormal spatial interactions and increasing deficiencies with increasing spatial frequencies. These abnormalities depended on the axis of astigmatism (in meridional amblyopia) and were more pronounced in strabismic than in anisometropic amblyopia. Spatial interactions were independent on the contrast-detection thresholds. Thus, adults with amblyopia might perform as well as normal observers for some stimulus parameters and abnormally for others. Our results indicate a close relationship between abnormal visual input to the visual cortex during development and abnormal functionality of the collinear spatial interactions in adults with amblyopia.

Original languageEnglish
Pages (from-to)1471-1479
Number of pages9
JournalVision Research
Volume45
Issue number11
DOIs
StatePublished - May 2005

Keywords

  • Amblyopia
  • Facilitation
  • Lateral interaction
  • Spatial interaction
  • Suppression

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