Spatial Features and Functional Implications of Plant 3D Genome Organization

Katherine Domb, Nan Wang, Guillaume Hummel, Chang Liu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The advent of high-throughput sequencing-based methods for chromatin conformation, accessibility, and immunoprecipitation assays has been a turning point in 3D genomics. Altogether, these new tools have been pushing upward the interpretation of pioneer cytogenetic evidence for a higher order in chromatin packing. Here, we review the latest development in our understanding of plant spatial genome structures and different levels of organization and discuss their functional implications. Then, we spotlight the complexity of organellar (i.e., mitochondria and plastids) genomes and discuss their 3D packing into nucleoids. Finally, we propose unaddressed research axes to investigate functional links between chromatin-like dynamics and transcriptional regulation within organellar nucleoids.

Original languageEnglish
Pages (from-to)173-200
Number of pages28
JournalAnnual Review of Plant Biology
StatePublished - 2022
Externally publishedYes


  • 3D genomes
  • TADs
  • chromatin
  • nucleoids
  • organelles
  • polyploidy
  • topologically associated domains


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