Some properties of the plasma hGH activity in patients with laron-type dwarfism determined by a radioreceptor assay using human liver tissue

R. Eshet; S. Peleg; Z. Josefsberg; C. Fuchs; R. Arnon; Z. Laron

doi:10.1159/000180106

Some properties of the plasma hGH activity in patients with laron-type dwarfism determined by a radioreceptor assay using human liver tissue

R. Eshet
, S. Peleg
, Z. Josefsberg
, C. Fuchs
, R. Arnon
, Z. Laron^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A radioreceptor assay for human growth hormone (hGH) using the 100,000-g pellet of human liver tissue homogenates obtained from a 13-year-oid male donor of a kidney transplantation is described. The dilution curves of the plasma hGH of 6 patients with Laron-type dwarfism (LTD) as well as those of the plasma hGH from I normal child and 2 acromegalic patients were all found to be parallel to the standard curve, suggesting that in the LTD syndrome the circulating hGH is biologically active.

Original language	English
Pages (from-to)	276-283
Number of pages	8
Journal	Hormone Research in Paediatrics
Volume	22
Issue number	4
DOIs	https://doi.org/10.1159/000180106
State	Published - 1985

Keywords

Human liver receptors
hGH radioreceptor assay
hGH receptors

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10.1159/000180106

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title = "Some properties of the plasma hGH activity in patients with laron-type dwarfism determined by a radioreceptor assay using human liver tissue",

abstract = "A radioreceptor assay for human growth hormone (hGH) using the 100,000-g pellet of human liver tissue homogenates obtained from a 13-year-oid male donor of a kidney transplantation is described. The dilution curves of the plasma hGH of 6 patients with Laron-type dwarfism (LTD) as well as those of the plasma hGH from I normal child and 2 acromegalic patients were all found to be parallel to the standard curve, suggesting that in the LTD syndrome the circulating hGH is biologically active.",

keywords = "Human liver receptors, hGH radioreceptor assay, hGH receptors",

author = "R. Eshet and S. Peleg and Z. Josefsberg and C. Fuchs and R. Arnon and Z. Laron",

year = "1985",

doi = "10.1159/000180106",

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AU - Eshet, R.

AU - Peleg, S.

AU - Josefsberg, Z.

AU - Fuchs, C.

AU - Arnon, R.

AU - Laron, Z.

PY - 1985

Y1 - 1985

N2 - A radioreceptor assay for human growth hormone (hGH) using the 100,000-g pellet of human liver tissue homogenates obtained from a 13-year-oid male donor of a kidney transplantation is described. The dilution curves of the plasma hGH of 6 patients with Laron-type dwarfism (LTD) as well as those of the plasma hGH from I normal child and 2 acromegalic patients were all found to be parallel to the standard curve, suggesting that in the LTD syndrome the circulating hGH is biologically active.

AB - A radioreceptor assay for human growth hormone (hGH) using the 100,000-g pellet of human liver tissue homogenates obtained from a 13-year-oid male donor of a kidney transplantation is described. The dilution curves of the plasma hGH of 6 patients with Laron-type dwarfism (LTD) as well as those of the plasma hGH from I normal child and 2 acromegalic patients were all found to be parallel to the standard curve, suggesting that in the LTD syndrome the circulating hGH is biologically active.

KW - Human liver receptors

KW - hGH radioreceptor assay

KW - hGH receptors

UR - https://www.scopus.com/pages/publications/0022383201

U2 - 10.1159/000180106

DO - 10.1159/000180106

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AN - SCOPUS:0022383201

SN - 1663-2818

VL - 22

SP - 276

EP - 283

JO - Hormone Research in Paediatrics

JF - Hormone Research in Paediatrics

IS - 4

ER -

Some properties of the plasma hGH activity in patients with laron-type dwarfism determined by a radioreceptor assay using human liver tissue

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