Some molecular properties of an isolated acetylcholine receptor ion-translocation protein

D. Michaelson, R. Vandlen, J. Bode, T. Moody, J. Schmidt, M. A. Raftery

Research output: Contribution to journalArticlepeer-review

Abstract

An improved procedure for isolation and purification of acetylcholine receptor from Torpedo californica electroplax membranes is described. The purified material contains the neurotransmitter recognition site and a second binding subsite which complexes inorganic cations and bis-quaternary cholinergic analogs. In addition to the transmitter recognition site the isolated macromolecule contains the molecular features necessary for ion-translocation during postsynaptic depolarization, since a chemically excitable membrane can be formed from purified acetylcholine receptor and Torpedo phospholipids.

Original languageEnglish
Pages (from-to)796-804
Number of pages9
JournalArchives of Biochemistry and Biophysics
Volume165
Issue number2
DOIs
StatePublished - Dec 1974
Externally publishedYes

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