TY - JOUR
T1 - Some guidelines for identification of recognition sequences
T2 - Regulatory sequences frequently contain (T)GTG/CAC(A), TGA/TCA and (T)CTC/GAG(A)
AU - Nussinov, Ruth
PY - 1986/3/26
Y1 - 1986/3/26
N2 - Inspection of many proposed recognition signal sequences shows that TGTG/CACA, GAGA/TCTC or their triplet subsets, and TGA/TCA occur frequently. These repeated elements, conserved in recognition sequences from evolutionarily distant organisms, are likely to possess unique structural characteristics. Recurrence of these oligomers may aid in identification of further regulatory sequences in upstream or other regions. Another class of recognition sequences is GC-rich. At present there are only a few examples of this class. It is likely that these sequences function via a different mechanism.
AB - Inspection of many proposed recognition signal sequences shows that TGTG/CACA, GAGA/TCTC or their triplet subsets, and TGA/TCA occur frequently. These repeated elements, conserved in recognition sequences from evolutionarily distant organisms, are likely to possess unique structural characteristics. Recurrence of these oligomers may aid in identification of further regulatory sequences in upstream or other regions. Another class of recognition sequences is GC-rich. At present there are only a few examples of this class. It is likely that these sequences function via a different mechanism.
KW - Recognition sequence
KW - Regulatory sequence
UR - http://www.scopus.com/inward/record.url?scp=0022448415&partnerID=8YFLogxK
U2 - 10.1016/0167-4781(86)90106-5
DO - 10.1016/0167-4781(86)90106-5
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AN - SCOPUS:0022448415
SN - 0167-4781
VL - 866
SP - 93
EP - 108
JO - BBA - Gene Structure and Expression
JF - BBA - Gene Structure and Expression
IS - 2-3
ER -