Some aspects of the action of hexachlorophene in rats infected with Fasciola hepatica

M. Goldberg; D. Gold

doi:10.1016/0306-4492(76)90072-1

Some aspects of the action of hexachlorophene in rats infected with Fasciola hepatica

M. Goldberg^*
, D. Gold

^*Corresponding author for this work

Clinical Microbiology and Immunology

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

1. A single dose of hexachlorophene (40 mg/kg) given to albino rats 4, 8 and 12 weeks after their experimental infection with Fasciola hepatica, produced marked lethal effect on the flukes 6-15 days post treatment, and significant changes in the glutamate oxalacetate transaminase (GOT) and sorbitol dehydrogenase (SDH) levels in the serum and liver of the rats. 2. In 8 and 12-week infections, hexachlorophene administration produced a transient "toxic" effect with marked blood neutrophilia.

Original language	English
Pages (from-to)	103-107
Number of pages	5
Journal	Comparative biochemistry and physiology. C: Comparative pharmacology
Volume	54
Issue number	2
DOIs	https://doi.org/10.1016/0306-4492(76)90072-1
State	Published - 1976

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AB - 1. A single dose of hexachlorophene (40 mg/kg) given to albino rats 4, 8 and 12 weeks after their experimental infection with Fasciola hepatica, produced marked lethal effect on the flukes 6-15 days post treatment, and significant changes in the glutamate oxalacetate transaminase (GOT) and sorbitol dehydrogenase (SDH) levels in the serum and liver of the rats. 2. In 8 and 12-week infections, hexachlorophene administration produced a transient "toxic" effect with marked blood neutrophilia.

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Some aspects of the action of hexachlorophene in rats infected with Fasciola hepatica

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