TY - JOUR
T1 - Some aspects of the action of hexachlorophene in rats infected with Fasciola hepatica
AU - Goldberg, M.
AU - Gold, D.
PY - 1976
Y1 - 1976
N2 - 1. A single dose of hexachlorophene (40 mg/kg) given to albino rats 4, 8 and 12 weeks after their experimental infection with Fasciola hepatica, produced marked lethal effect on the flukes 6-15 days post treatment, and significant changes in the glutamate oxalacetate transaminase (GOT) and sorbitol dehydrogenase (SDH) levels in the serum and liver of the rats. 2. In 8 and 12-week infections, hexachlorophene administration produced a transient "toxic" effect with marked blood neutrophilia.
AB - 1. A single dose of hexachlorophene (40 mg/kg) given to albino rats 4, 8 and 12 weeks after their experimental infection with Fasciola hepatica, produced marked lethal effect on the flukes 6-15 days post treatment, and significant changes in the glutamate oxalacetate transaminase (GOT) and sorbitol dehydrogenase (SDH) levels in the serum and liver of the rats. 2. In 8 and 12-week infections, hexachlorophene administration produced a transient "toxic" effect with marked blood neutrophilia.
UR - http://www.scopus.com/inward/record.url?scp=0017158153&partnerID=8YFLogxK
U2 - 10.1016/0306-4492(76)90072-1
DO - 10.1016/0306-4492(76)90072-1
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AN - SCOPUS:0017158153
SN - 0306-4492
VL - 54
SP - 103
EP - 107
JO - Comparative biochemistry and physiology. C: Comparative pharmacology
JF - Comparative biochemistry and physiology. C: Comparative pharmacology
IS - 2
ER -