Somatic gene targeting in the developing and adult mouse retina

Research output: Contribution to journalArticlepeer-review

Abstract

Retinogenesis is a developmental process that is tightly regulated both temporally and spatially and is therefore an excellent model system for studying the molecular and cellular mechanisms of neurogenesis in the central nervous system. Understanding of these events in vivo is greatly facilitated by the availability of mouse mutant models, including those with natural or targeted mutations and those with conditional knockout or forced expression of genes. This article reviews these genetic modifications and their contribution to the study of retinogenesis in mammals, with special emphasis on conditional gene targeting approaches.

Original languageEnglish
Pages (from-to)457-464
Number of pages8
JournalMethods
Volume28
Issue number4
DOIs
StatePublished - 1 Dec 2002

Keywords

  • Conditional knockout
  • Cre/loxP
  • Gene targeting
  • Pax6
  • Retinogenesis

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