Solvent effects on the helix–coil transition in polypeptides

Mordechai Bixon*, Shneior Lifson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A simple way to incorporate the solvent–peptide interaction in any available theory of the helix–coil transition is developed. The competition between the intramolecular hydrogen bonding and the solvent–polymer hydrogen bonding is considered in multi‐component solvents where some of the components have hydrogen‐bonding capacity. Molecular averages are computed by using the theory of Lifson and Roig. The experimental data of Yang are analyzed, and the range of acceptable values of the equilibrium constants of hydrogen bond formation is deduced. The enthalpy of the transition in multicomponent solvents is calculated.

Original languageEnglish
Pages (from-to)815-821
Number of pages7
Issue number8
StatePublished - Sep 1966
Externally publishedYes


Dive into the research topics of 'Solvent effects on the helix–coil transition in polypeptides'. Together they form a unique fingerprint.

Cite this