Soluble intercellular adhesion molecule 1 in umbilical cord serum: Potential for the diagnosis of neonatal infections

Emile Daraï, Christophe Poncelet, David Soriano, Veronique Lejeune, Annie France Bringuier, Patrick Madelenat, Gerard Feldmann, Jean Yves Scoazec

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate the diagnostic relevance to neonatal infections of the soluble intercellular adhesion molecule 1 (sICAM-1) cord serum level. Methods: The case-control study included 66 term newborn infants with and without risk factors for neonatal infections. Cord blood serum determinations of white blood cell count, C-reactive protein, fibrinogen, and sICAM-1 were systematically performed associated with bacterial cultures from placenta, ears, and gastric fluids. Results: 6 of 33 infants (18.2%) with risk factors were infected, and 13 (39.4%) were colonized. Two infants included in the group without infection risk factors (n = 33) were colonized. No difference in sICAM-1 cord serum levels was found according to the presence of premature rupture of membrane, fetal tachycardia > 1160 bpm, meconial amniotic fluid, and duration of labour > 110 h. No difference in sICAM-1 was noted between infected and non-infected infants. The cord serum levels of sICAM-1 were significantly higher in infants after forceps extraction (p = 0.01). A correlation was observed between sICAM-1 and C-reactive protein cord serum levels (p = 0.004, r = 0.371) and between sICAM-1 level and neutrophil count (p = 0.01, r = 0.489). Conclusions: Our results suggest that cord serum sICAM-1 determinations have no diagnostic relevance to neonatal infection. The increase of sICAM-1 cord serum levels in infants after forceps extraction suggests its potential to evaluate cerebral trauma or hypoxia.

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalFetal Diagnosis and Therapy
Volume17
Issue number3
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • C-reactive protein
  • Fibrinogen
  • Neonatal infections
  • Soluble intercellular adhesion molecule 1

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