Soluble HLA class I in colon cancer

B. Klein, T. Klein, A. Figer, J. Shapira, E. Livni, I. Levin, H. Luria

Research output: Contribution to journalArticlepeer-review


Serum β-2 microglobulin (β-2M) was measured in 250 colon cancer patients and 210 controls. The patients were divided in three groups: Group A, 49 healthy newly diagnosed patients, Group B, 146 patients on long-term follow-up, and Group C, 56 patients with metastases. β-2M was measured by an ELISA technique. The mean β-2M ± 1SD in all the cancer patients (4.4 ± 1.6) was significantly higher than in age-matched controls (1.29 ± 0.49)(p < 0.001) When the three groups were compared to each other the mean β-2M level of group A was similar to that of group C. Both differed significantly from the mean β-2M of group B, There was a good correlation between CEA level and β-2M level and metastasis. However, in 15 patients of Group B, metastases were observed with an elevated β-2M level but a normal CEA level. We conclude that the assessment of β-2M by a single ELISA technique is of value in evaluation of metastasis especially in patients with normal CEA levels.

Original languageEnglish
Pages (from-to)322-325
Number of pages4
JournalCancer Journal
Issue number5
StatePublished - 1991
Externally publishedYes


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