Solitary pulmonary cholesteroloma, multiple xanthelasmas and lipemia retinalis complicating hypercholesterolemia after bone marrow transplantation

A. Toren, A. Nagler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A 22-year-old female with diffuse mixed T cell lymphoma in second complete remission underwent allogeneic BMT from her HLA-compatible brother. Transplantation was complicated by acute graft-versus-host disease (GVHD), cytomegalovirus (CMV) infection, and combined hepatotoxic/cholestatic liver disease 45 days post-BMT. Cholesterol levels reached 65 mmol/l, and high density lipoprotein (HDL) cholesterol decreased to 0.23 mmol/l. She developed skin xanthelasmas, lipemia retinalis, and a solitary lung lesion, which was clinically diagnosed as pulmonary cholesteroloma. All these complications resolved following plasmapheresis and hypolipidemic treatment with lovastatin and cholesterol levels normalized.

Original languageEnglish
Pages (from-to)457-459
Number of pages3
JournalBone Marrow Transplantation
Volume18
Issue number2
StatePublished - Aug 1996

Keywords

  • Cytomegalovirus infection
  • Graft-versus-host disease
  • Hypercholesterolemia
  • Hyperlipidemia
  • Lipemia retinalis
  • Xanthelasma

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