Solid phase chemical ligation employing a rink amide linker for the synthesis of histone H2B protein

Muhammad Jbara; Mallikanti Seenaiah; Ashraf Brik

doi:10.1039/c4cc06499b

Solid phase chemical ligation employing a rink amide linker for the synthesis of histone H2B protein

Muhammad Jbara, Mallikanti Seenaiah, Ashraf Brik^*

^*Corresponding author for this work

Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Presented here is a solid phase chemical ligation strategy employing native chemical ligation and the commercially available Rink-amide linker as a key element in our approach. The method was applied for the synthesis of histone H2B, which sets the ground for the rapid preparation of posttranslationally modified analogues of this protein.

Original language	English
Pages (from-to)	12534-12537
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	83
DOIs	https://doi.org/10.1039/c4cc06499b
State	Published - 18 Sep 2014
Externally published	Yes

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abstract = "Presented here is a solid phase chemical ligation strategy employing native chemical ligation and the commercially available Rink-amide linker as a key element in our approach. The method was applied for the synthesis of histone H2B, which sets the ground for the rapid preparation of posttranslationally modified analogues of this protein.",

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Solid phase chemical ligation employing a rink amide linker for the synthesis of histone H2B protein

Abstract

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