Solid organ transplantation worsens the prognosis of patients with cutaneous squamous cell carcinoma of the head and neck region—Comparison between solid organ transplant recipients and immunocompetent patients

Amit Ritter*, Samih Badir, Muhammad Mansour, Zvi Segal, Dean Ad-El, Gideon Bachar, Thomas Shpitzer, Aron Popovtzer, Aviram Mizrachi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Cutaneous squamous cell carcinoma of the head and neck (CSCC-HN) appears to behave more aggressively in immunosuppressed patients. We aimed to investigate this hypothesis by comparing solid organ transplant recipients (SOTR) with CSCC-HN to immunocompetent patients. Methods: A retrospective comparative study was conducted for SOTR and immunocompetent patients who were treated for CSCC-HN. Results: A total of 177 SOTR and 157 immunocompetent patients with CSCC-HN were included. Lymph node metastases were more common in the SOTR group (9% vs 3%), and distant metastases occurred only in SOTR (3% of patients). SOTR had a higher rate of recurrences (19% vs 10%), which were mostly regional (7%) and distant (3%). The 2-year disease-specific survival of SOTR was lower (93% vs 100%). Conclusions: SOTR with CSCC-HN has significantly worse outcomes compared to immunocompetent patients. Solid-organ transplantation should be regarded as a negative prognostic factor in patients with CSCC-HN.

Original languageEnglish
Pages (from-to)884-894
Number of pages11
JournalHead and Neck
Volume43
Issue number3
DOIs
StatePublished - Mar 2021

Keywords

  • head and neck cancer
  • skin cancer
  • solid organ
  • squamous cell carcinoma
  • transplantation

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