Solar insolation in springtime influences age of onset of bipolar I disorder

M. Bauer; T. Glenn; M. Alda; M. A. Aleksandrovich; O. A. Andreassen; E. Angelopoulos; R. Ardau; Y. Ayhan; C. Baethge; S. R. Bharathram; R. Bauer; B. T. Baune; C. Becerra-Palars; F. Bellivier; R. H. Belmaker; M. Berk; Y. Bersudsky; Bicakci; H. Birabwa-Oketcho; T. D. Bjella; L. Bossini; J. Cabrera; E. Y.W. Cheung; M. Del Zompo; S. Dodd; M. Donix; B. Etain; A. Fagiolini; K. N. Fountoulakis; M. A. Frye; A. Gonzalez-Pinto; J. F. Gottlieb; P. Grof; H. Harima; C. Henry; E. T. Isometsä; S. Janno; F. Kapczinski; M. Kardell; S. Khaldi; S. Kliwicki; B. König; T. L. Kot; R. Krogh; M. Kunz; B. Lafer; M. Landén; E. R. Larsen; U. Lewitzka; R. W. Licht; C. Lopez-Jaramillo; G. MacQueen; M. Manchia; W. Marsh; M. Martinez-Cengotitabengoa; I. Melle; F. Meza-Urzúa; M. Yee Ming; S. Monteith; G. Morken; E. Mosca; R. Munoz; S. V. Mythri; F. Nacef; R. K. Nadella; F. G. Nery; R. E. Nielsen; C. O'Donovan; A. Omrani; Y. Osher; H. Østermark Sørensen; U. Ouali; Y. Pica Ruiz; M. Pilhatsch; M. Pinna; F. D.R. da Ponte; D. Quiroz; R. Ramesar; N. Rasgon; M. S. Reddy; A. Reif; P. Ritter; J. K. Rybakowski; K. Sagduyu; M. Scippa; E. Severus; C. Simhandl; D. J. Stein; S. Strejilevich; M. Subramaniam; A. H. Sulaiman; K. Suominen; H. Tagata; Y. Tatebayashi; L. Tondo; C. Torrent; A. E. Vaaler; J. Veeh; E. Vieta; B. Viswanath; M. Yoldi-Negrete; M. Zetin; Y. Zgueb; P. C. Whybrow

doi:10.1111/acps.12772

Solar insolation in springtime influences age of onset of bipolar I disorder

M. Bauer^*, T. Glenn, M. Alda, M. A. Aleksandrovich, O. A. Andreassen, E. Angelopoulos, R. Ardau, Y. Ayhan, C. Baethge, S. R. Bharathram, R. Bauer, B. T. Baune, C. Becerra-Palars, F. Bellivier, R. H. Belmaker, M. Berk, Y. Bersudsky, Bicakci, H. Birabwa-Oketcho, T. D. BjellaL. Bossini, J. Cabrera, E. Y.W. Cheung, M. Del Zompo, S. Dodd, M. Donix, B. Etain, A. Fagiolini, K. N. Fountoulakis, M. A. Frye, A. Gonzalez-Pinto, J. F. Gottlieb, P. Grof, H. Harima, C. Henry, E. T. Isometsä, S. Janno, F. Kapczinski, M. Kardell, S. Khaldi, S. Kliwicki, B. König, T. L. Kot, R. Krogh, M. Kunz, B. Lafer, M. Landén, E. R. Larsen, U. Lewitzka, R. W. Licht, C. Lopez-Jaramillo, G. MacQueen, M. Manchia, W. Marsh, M. Martinez-Cengotitabengoa, I. Melle, F. Meza-Urzúa, M. Yee Ming, S. Monteith, G. Morken, E. Mosca, R. Munoz, S. V. Mythri, F. Nacef, R. K. Nadella, F. G. Nery, R. E. Nielsen, C. O'Donovan, A. Omrani, Y. Osher, H. Østermark Sørensen, U. Ouali, Y. Pica Ruiz, M. Pilhatsch, M. Pinna, F. D.R. da Ponte, D. Quiroz, R. Ramesar, N. Rasgon, M. S. Reddy, A. Reif, P. Ritter, J. K. Rybakowski, K. Sagduyu, M. Scippa, E. Severus, C. Simhandl, D. J. Stein, S. Strejilevich, M. Subramaniam, A. H. Sulaiman, K. Suominen, H. Tagata, Y. Tatebayashi, L. Tondo, C. Torrent, A. E. Vaaler, J. Veeh, E. Vieta, B. Viswanath, M. Yoldi-Negrete, M. Zetin, Y. Zgueb, P. C. Whybrow

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. Results: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). Conclusion: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.

Original language	English
Pages (from-to)	571-582
Number of pages	12
Journal	Acta Psychiatrica Scandinavica
Volume	136
Issue number	6
DOIs	https://doi.org/10.1111/acps.12772
State	Published - Dec 2017
Externally published	Yes

Funding

Funders	Funder number
2ChronoRecord Association
41Department of Medical Epidemiology and Biostatistics
43Department of Clinical Medicine, Aalborg University
53Asha Bipolar Clinic
60Department of Psychiatry and Behavioral Sciences
63Department of Neuroscience and Mental Health
70McLean Hospital-Harvard Medical School
71Mood Disorder Lucio Bini Centers, Cagliari e Roma
73Consejo Nacional de Ciencia y Tecnología
75Department of Psychiatry and Biobehavioral Sciences
AOUS
Asha Hospital
Capodistrian University of Athens
Centre for Youth Mental Health
Denis Diderot University
Division of Mental Health and Addiction
Favaloro University
Federal University of Bahia
Florey Institute for Neuroscience and Mental Health
Hopitaux Universitaires Henri Mondor
IMRB
INSERM U955
Institute of Neuroscience and Physiology
K.G. Jebsen Centre for Psychosis Research
Mayo Clinic Depression Center
Michigan State University College of Human Medicine, Traverse City
National Centre for Excellence in Youth Mental Health
Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Pratiksha trust
RenéDescartes University
Sahlgrenska Academy, University of Gothenburg
School of Medicine, Aristotle University of Thessaloniki
Stanford School of Medicine
Swedish federal government	ALFGBG-142041, ALF 20130032
Tokyo Metropolitan Matsuzawa Hospital
UnitéPerception et Mémoire
Universidade Federal do Rio Grande do Sul, Porto Alegre
University Hospital Carl Gustav Carus
University of Cologne Medical School
University of Helsinki and Helsinki University Hospital
University of Missouri Kansas City School of Medicine, Kansas City
University of Siena Medical Center
University of São Paulo Medical School
UniversitéParis Est
Mayo Clinic
Northwestern University
University of California, Los Angeles
University of California, San Diego
Feinberg School of Medicine
Norges Teknisk-Naturvitenskapelige Universitet
Chapman University
Neuroscience Institute, University of Tennessee
Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles
Università degli Studi di Siena
Tokyo Metropolitan Institute of Medical Science
School of Medicine, University of Maryland
Fondation FondaMental
National Institute of Mental Health and Neurosciences
National Health and Medical Research Council	1059660
Department of Biotechnology, Ministry of Science and Technology, India
Department of Science and Technology, Ministry of Science and Technology, India
Institut national de la santé et de la recherche médicale	UMR-S1144
Stiftelsen för Strategisk Forskning	KF10-0039
Deakin University
University of Melbourne
Technische Universität Dresden
Euskal Herriko Unibertsitatea
Institut Pasteur
Karolinska Institutet
Vetenskapsrådet	K2010-61P-21568-01-4, K2014-62X-14647-12-51
Universiti Malaya
Ben-Gurion University of the Negev
Universidad de Antioquia
Hacettepe Üniversitesi
Norges Forskningsråd	223273
Göteborgs Universitet
Sahlgrenska Akademin
Universitat de Barcelona
Centro de Investigación Biomédica en Red de Salud Mental
Tartu Ülikool
Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu
Université de Tunis El Manar

Keywords

bipolar disorder
circadian rhythm
epidemiology
solar insolation

Access to Document

10.1111/acps.12772

Cite this

Bauer, M., Glenn, T., Alda, M., Aleksandrovich, M. A., Andreassen, O. A., Angelopoulos, E., Ardau, R., Ayhan, Y., Baethge, C., Bharathram, S. R., Bauer, R., Baune, B. T., Becerra-Palars, C., Bellivier, F., Belmaker, R. H., Berk, M., Bersudsky, Y., Bicakci, Birabwa-Oketcho, H., ... Whybrow, P. C. (2017). Solar insolation in springtime influences age of onset of bipolar I disorder. Acta Psychiatrica Scandinavica, 136(6), 571-582. https://doi.org/10.1111/acps.12772

@article{6e2c793e3a9d43048a5a3724be2fdb77,

title = "Solar insolation in springtime influences age of onset of bipolar I disorder",

abstract = "Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. Results: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). Conclusion: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.",

keywords = "bipolar disorder, circadian rhythm, epidemiology, solar insolation",

author = "M. Bauer and T. Glenn and M. Alda and Aleksandrovich, {M. A.} and Andreassen, {O. A.} and E. Angelopoulos and R. Ardau and Y. Ayhan and C. Baethge and Bharathram, {S. R.} and R. Bauer and Baune, {B. T.} and C. Becerra-Palars and F. Bellivier and Belmaker, {R. H.} and M. Berk and Y. Bersudsky and Bicakci and H. Birabwa-Oketcho and Bjella, {T. D.} and L. Bossini and J. Cabrera and Cheung, {E. Y.W.} and {Del Zompo}, M. and S. Dodd and M. Donix and B. Etain and A. Fagiolini and Fountoulakis, {K. N.} and Frye, {M. A.} and A. Gonzalez-Pinto and Gottlieb, {J. F.} and P. Grof and H. Harima and C. Henry and Isomets{\"a}, {E. T.} and S. Janno and F. Kapczinski and M. Kardell and S. Khaldi and S. Kliwicki and B. K{\"o}nig and Kot, {T. L.} and R. Krogh and M. Kunz and B. Lafer and M. Land{\'e}n and Larsen, {E. R.} and U. Lewitzka and Licht, {R. W.} and C. Lopez-Jaramillo and G. MacQueen and M. Manchia and W. Marsh and M. Martinez-Cengotitabengoa and I. Melle and F. Meza-Urz{\'u}a and {Yee Ming}, M. and S. Monteith and G. Morken and E. Mosca and R. Munoz and Mythri, {S. V.} and F. Nacef and Nadella, {R. K.} and Nery, {F. G.} and Nielsen, {R. E.} and C. O'Donovan and A. Omrani and Y. Osher and {{\O}stermark S{\o}rensen}, H. and U. Ouali and {Pica Ruiz}, Y. and M. Pilhatsch and M. Pinna and {da Ponte}, {F. D.R.} and D. Quiroz and R. Ramesar and N. Rasgon and Reddy, {M. S.} and A. Reif and P. Ritter and Rybakowski, {J. K.} and K. Sagduyu and M. Scippa and E. Severus and C. Simhandl and Stein, {D. J.} and S. Strejilevich and M. Subramaniam and Sulaiman, {A. H.} and K. Suominen and H. Tagata and Y. Tatebayashi and L. Tondo and C. Torrent and Vaaler, {A. E.} and J. Veeh and E. Vieta and B. Viswanath and M. Yoldi-Negrete and M. Zetin and Y. Zgueb and Whybrow, {P. C.}",

note = "Publisher Copyright: {\textcopyright} 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",

year = "2017",

month = dec,

doi = "10.1111/acps.12772",

language = "אנגלית",

volume = "136",

pages = "571--582",

journal = "Acta Psychiatrica Scandinavica",

issn = "0001-690X",

publisher = "John Wiley and Sons Inc.",

number = "6",

}

Bauer, M, Glenn, T, Alda, M, Aleksandrovich, MA, Andreassen, OA, Angelopoulos, E, Ardau, R, Ayhan, Y, Baethge, C, Bharathram, SR, Bauer, R, Baune, BT, Becerra-Palars, C, Bellivier, F, Belmaker, RH, Berk, M, Bersudsky, Y, Bicakci, Birabwa-Oketcho, H, Bjella, TD, Bossini, L, Cabrera, J, Cheung, EYW, Del Zompo, M, Dodd, S, Donix, M, Etain, B, Fagiolini, A, Fountoulakis, KN, Frye, MA, Gonzalez-Pinto, A, Gottlieb, JF, Grof, P, Harima, H, Henry, C, Isometsä, ET, Janno, S, Kapczinski, F, Kardell, M, Khaldi, S, Kliwicki, S, König, B, Kot, TL, Krogh, R, Kunz, M, Lafer, B, Landén, M, Larsen, ER, Lewitzka, U, Licht, RW, Lopez-Jaramillo, C, MacQueen, G, Manchia, M, Marsh, W, Martinez-Cengotitabengoa, M, Melle, I, Meza-Urzúa, F, Yee Ming, M, Monteith, S, Morken, G, Mosca, E, Munoz, R, Mythri, SV, Nacef, F, Nadella, RK, Nery, FG, Nielsen, RE, O'Donovan, C, Omrani, A, Osher, Y, Østermark Sørensen, H, Ouali, U, Pica Ruiz, Y, Pilhatsch, M, Pinna, M, da Ponte, FDR, Quiroz, D, Ramesar, R, Rasgon, N, Reddy, MS, Reif, A, Ritter, P, Rybakowski, JK, Sagduyu, K, Scippa, M, Severus, E, Simhandl, C, Stein, DJ, Strejilevich, S, Subramaniam, M, Sulaiman, AH, Suominen, K, Tagata, H, Tatebayashi, Y, Tondo, L, Torrent, C, Vaaler, AE, Veeh, J, Vieta, E, Viswanath, B, Yoldi-Negrete, M, Zetin, M, Zgueb, Y & Whybrow, PC 2017, 'Solar insolation in springtime influences age of onset of bipolar I disorder', Acta Psychiatrica Scandinavica, vol. 136, no. 6, pp. 571-582. https://doi.org/10.1111/acps.12772

TY - JOUR

T1 - Solar insolation in springtime influences age of onset of bipolar I disorder

AU - Bauer, M.

AU - Glenn, T.

AU - Alda, M.

AU - Aleksandrovich, M. A.

AU - Andreassen, O. A.

AU - Angelopoulos, E.

AU - Ardau, R.

AU - Ayhan, Y.

AU - Baethge, C.

AU - Bharathram, S. R.

AU - Bauer, R.

AU - Baune, B. T.

AU - Becerra-Palars, C.

AU - Bellivier, F.

AU - Belmaker, R. H.

AU - Berk, M.

AU - Bersudsky, Y.

AU - Bicakci,

AU - Birabwa-Oketcho, H.

AU - Bjella, T. D.

AU - Bossini, L.

AU - Cabrera, J.

AU - Cheung, E. Y.W.

AU - Del Zompo, M.

AU - Dodd, S.

AU - Donix, M.

AU - Etain, B.

AU - Fagiolini, A.

AU - Fountoulakis, K. N.

AU - Frye, M. A.

AU - Gonzalez-Pinto, A.

AU - Gottlieb, J. F.

AU - Grof, P.

AU - Harima, H.

AU - Henry, C.

AU - Isometsä, E. T.

AU - Janno, S.

AU - Kapczinski, F.

AU - Kardell, M.

AU - Khaldi, S.

AU - Kliwicki, S.

AU - König, B.

AU - Kot, T. L.

AU - Krogh, R.

AU - Kunz, M.

AU - Lafer, B.

AU - Landén, M.

AU - Larsen, E. R.

AU - Lewitzka, U.

AU - Licht, R. W.

AU - Lopez-Jaramillo, C.

AU - MacQueen, G.

AU - Manchia, M.

AU - Marsh, W.

AU - Martinez-Cengotitabengoa, M.

AU - Melle, I.

AU - Meza-Urzúa, F.

AU - Yee Ming, M.

AU - Monteith, S.

AU - Morken, G.

AU - Mosca, E.

AU - Munoz, R.

AU - Mythri, S. V.

AU - Nacef, F.

AU - Nadella, R. K.

AU - Nery, F. G.

AU - Nielsen, R. E.

AU - O'Donovan, C.

AU - Omrani, A.

AU - Osher, Y.

AU - Østermark Sørensen, H.

AU - Ouali, U.

AU - Pica Ruiz, Y.

AU - Pilhatsch, M.

AU - Pinna, M.

AU - da Ponte, F. D.R.

AU - Quiroz, D.

AU - Ramesar, R.

AU - Rasgon, N.

AU - Reddy, M. S.

AU - Reif, A.

AU - Ritter, P.

AU - Rybakowski, J. K.

AU - Sagduyu, K.

AU - Scippa, M.

AU - Severus, E.

AU - Simhandl, C.

AU - Stein, D. J.

AU - Strejilevich, S.

AU - Subramaniam, M.

AU - Sulaiman, A. H.

AU - Suominen, K.

AU - Tagata, H.

AU - Tatebayashi, Y.

AU - Tondo, L.

AU - Torrent, C.

AU - Vaaler, A. E.

AU - Veeh, J.

AU - Vieta, E.

AU - Viswanath, B.

AU - Yoldi-Negrete, M.

AU - Zetin, M.

AU - Zgueb, Y.

AU - Whybrow, P. C.

PY - 2017/12

Y1 - 2017/12

N2 - Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. Results: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). Conclusion: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.

AB - Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. Results: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). Conclusion: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.

KW - bipolar disorder

KW - circadian rhythm

KW - epidemiology

KW - solar insolation

UR - http://www.scopus.com/inward/record.url?scp=85025072706&partnerID=8YFLogxK

U2 - 10.1111/acps.12772

DO - 10.1111/acps.12772

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C2 - 28722128

AN - SCOPUS:85025072706

SN - 0001-690X

VL - 136

SP - 571

EP - 582

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

IS - 6

ER -

Solar insolation in springtime influences age of onset of bipolar I disorder

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