TY - JOUR
T1 - Sodwanones G, H, and I, new cytotoxic triterpenes from a marine sponge
AU - Rudi, Amira
AU - Goldberg, Israel
AU - Stein, Zafra
AU - Kashman, Yoel
AU - Benayahu, Yehuda
AU - Schleyer, Michael
AU - Gravalos, M. D.Garcia
PY - 1995/11/1
Y1 - 1995/11/1
N2 - Three cytotoxic triterpenes, sodwanones G [51, H [6], and I [7], have been isolated from a marine sponge. The three structures were determined by interpretation of nmr spectra, and in the case of 5, also on the basis of the X-ray diffraction analysis. The X-ray diffraction analysis of two other earlier reported sodwanones, E [3] and F [4] is also discussed. The cytotoxic activity against several cancer cell lines, has been tested. IC,0 values between 20 and 0.02 μM were obtained. Compounds 5 and 6 were 10- and 500-fold, respectively, more cytotoxic to A-549 cells than to any of the other cell lines tested (HT-29, MEL-28, P-388).
AB - Three cytotoxic triterpenes, sodwanones G [51, H [6], and I [7], have been isolated from a marine sponge. The three structures were determined by interpretation of nmr spectra, and in the case of 5, also on the basis of the X-ray diffraction analysis. The X-ray diffraction analysis of two other earlier reported sodwanones, E [3] and F [4] is also discussed. The cytotoxic activity against several cancer cell lines, has been tested. IC,0 values between 20 and 0.02 μM were obtained. Compounds 5 and 6 were 10- and 500-fold, respectively, more cytotoxic to A-549 cells than to any of the other cell lines tested (HT-29, MEL-28, P-388).
UR - http://www.scopus.com/inward/record.url?scp=0029414994&partnerID=8YFLogxK
U2 - 10.1021/np50125a009
DO - 10.1021/np50125a009
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AN - SCOPUS:0029414994
SN - 0163-3864
VL - 58
SP - 1702
EP - 1712
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 11
ER -
