Sodwanones G, H, and I, new cytotoxic triterpenes from a marine sponge

Amira Rudi, Israel Goldberg, Zafra Stein, Yoel Kashman, Yehuda Benayahu, Michael Schleyer, M. D.Garcia Gravalos

Research output: Contribution to journalArticlepeer-review


Three cytotoxic triterpenes, sodwanones G [51, H [6], and I [7], have been isolated from a marine sponge. The three structures were determined by interpretation of nmr spectra, and in the case of 5, also on the basis of the X-ray diffraction analysis. The X-ray diffraction analysis of two other earlier reported sodwanones, E [3] and F [4] is also discussed. The cytotoxic activity against several cancer cell lines, has been tested. IC,0 values between 20 and 0.02 μM were obtained. Compounds 5 and 6 were 10- and 500-fold, respectively, more cytotoxic to A-549 cells than to any of the other cell lines tested (HT-29, MEL-28, P-388).

Original languageEnglish
Pages (from-to)1702-1712
Number of pages11
JournalJournal of Natural Products
Issue number11
StatePublished - 1 Nov 1995


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