Sodium valproate and clozapine induced neutropenia: A case control study using register data

Steffi Malik, John Lally, Olesya Ajnakina, Megan Pritchard, Amir Krivoy, Fiona Gaughran, Hitesh Shetty, Robert J. Flanagan, James H. MacCabe

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The use of clozapine is limited due to the occurrence of neutropenia, and the rare but life threatening adverse event of agranulocytosis. There is little epidemiological research into clinical factors that may impact on this risk. We conducted a case control study examining the clinical risk factors for neutropenia patients treated with clozapine. Method: A case-control study was conducted within a database of anonymised electronic clinical records. All patients who discontinued clozapine due to a neutropenic event were included as cases. Matched controls were selected from patients with a documented clozapine exposure at the time of the clozapine neutropenic event of the case patient, matched by duration of clozapine treatment. Results: 136 cases and 136 controls were included. In multivariable analysis, the concurrent use of sodium valproate was associated with neutropenia (Odds Raito (OR) 2.28, 95%CI: 1.27–4.11, p = 0.006). There was a dose-response effect, with greater associations for higher doses. Patients who discontinued clozapine due to neutropenia were more likely to be of black ethnicity (OR 2.99, p < 0.001), were younger (t = 5.86, df = 267, p < 0.001), and received lower doses of clozapine (t = − 2.587, p = 0.01) than those who did not develop neutropenia. Conclusion: We identified an association between the concurrent use of sodium valproate and an increased risk of clozapine associated neutropenia. These results, taken in combination with the results from previous case series, suggest that the risk of clozapine associated neutropenia could be reduced by avoiding concurrent valproate treatment.

Original languageEnglish
Pages (from-to)267-273
Number of pages7
JournalSchizophrenia Research
Volume195
DOIs
StatePublished - May 2018
Externally publishedYes

Keywords

  • Agranulocytosis
  • Clozapine
  • Neutropenia
  • Schizophrenia
  • Treatment resistant
  • Valproate

Fingerprint

Dive into the research topics of 'Sodium valproate and clozapine induced neutropenia: A case control study using register data'. Together they form a unique fingerprint.

Cite this