Sodium channel localization in rat sciatic nerve following lead-induced demyelination

Hamutal Meiri; Sara Pri-Chen; Amos D. Korczyn

doi:10.1016/0006-8993(85)91444-1

Sodium channel localization in rat sciatic nerve following lead-induced demyelination

Hamutal Meiri^*, Sara Pri-Chen, Amos D. Korczyn

^*Corresponding author for this work

Physiology Pharmacology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Daily intraperitoneal injections of lead acetate for several weeks were followed by a peripheral neuropathy. The conduction of impulses in the sciatic nerve became slower, but their amplitude, duration and threshold remained normal. Sodium channel labeling with specific monoclonal antibodies revealed staining at demyelinated regions, while normal axons were stained exclusively at nodes of Ranvier. These results support the view that remodelling of sodium channel distribution may contribute to impulse conduction in demyelinated fibers.

Original language	English
Pages (from-to)	326-331
Number of pages	6
Journal	Brain Research
Volume	359
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(85)91444-1
State	Published - 16 Dec 1985

Keywords

heavy metal intoxication
lead
monoclonal antibody
peripheral neuropathy
sciatic nerve
sodium channel

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10.1016/0006-8993(85)91444-1

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title = "Sodium channel localization in rat sciatic nerve following lead-induced demyelination",

abstract = "Daily intraperitoneal injections of lead acetate for several weeks were followed by a peripheral neuropathy. The conduction of impulses in the sciatic nerve became slower, but their amplitude, duration and threshold remained normal. Sodium channel labeling with specific monoclonal antibodies revealed staining at demyelinated regions, while normal axons were stained exclusively at nodes of Ranvier. These results support the view that remodelling of sodium channel distribution may contribute to impulse conduction in demyelinated fibers.",

keywords = "heavy metal intoxication, lead, monoclonal antibody, peripheral neuropathy, sciatic nerve, sodium channel",

author = "Hamutal Meiri and Sara Pri-Chen and Korczyn, {Amos D.}",

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N2 - Daily intraperitoneal injections of lead acetate for several weeks were followed by a peripheral neuropathy. The conduction of impulses in the sciatic nerve became slower, but their amplitude, duration and threshold remained normal. Sodium channel labeling with specific monoclonal antibodies revealed staining at demyelinated regions, while normal axons were stained exclusively at nodes of Ranvier. These results support the view that remodelling of sodium channel distribution may contribute to impulse conduction in demyelinated fibers.

AB - Daily intraperitoneal injections of lead acetate for several weeks were followed by a peripheral neuropathy. The conduction of impulses in the sciatic nerve became slower, but their amplitude, duration and threshold remained normal. Sodium channel labeling with specific monoclonal antibodies revealed staining at demyelinated regions, while normal axons were stained exclusively at nodes of Ranvier. These results support the view that remodelling of sodium channel distribution may contribute to impulse conduction in demyelinated fibers.

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Sodium channel localization in rat sciatic nerve following lead-induced demyelination

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Keywords

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