TY - JOUR
T1 - Sodium butyrate enhances the activities of membranal enzymes and increases drug sensitivity in a cell line from ascitic fluid of an ovarian carcinoma patient
AU - Wasserman, Lina
AU - Beery, Einat
AU - Aviram, Rami
AU - Levavi, Hanoch
AU - Ovadia, Jardena
AU - Novogrodsky, Abraham
AU - Nordenberg, Jardena
PY - 1989/12
Y1 - 1989/12
N2 - The effect of sodium butyrate was examined on the growth and phenotypic expression of a cell line derived from the ascitic fluid of an untreated patient with ovarian carcinoma. The chemical inducer of differentiation, sodium butyrate, markedly enhances the activity of the membrane-bound glycoprotein enzymes, alkaline phosphatase and γ-glutamyl transpeptidase. The alkaline phosphatase corresponds to placental Regan type. Sodium butyrate (1 mM) alone has only a small inhibitory effect on cell growth. However, it was shown to potentiate the anti-proliferative effect of Adriamycin® and to render the cells sensitive to cis-platinum.
AB - The effect of sodium butyrate was examined on the growth and phenotypic expression of a cell line derived from the ascitic fluid of an untreated patient with ovarian carcinoma. The chemical inducer of differentiation, sodium butyrate, markedly enhances the activity of the membrane-bound glycoprotein enzymes, alkaline phosphatase and γ-glutamyl transpeptidase. The alkaline phosphatase corresponds to placental Regan type. Sodium butyrate (1 mM) alone has only a small inhibitory effect on cell growth. However, it was shown to potentiate the anti-proliferative effect of Adriamycin® and to render the cells sensitive to cis-platinum.
UR - http://www.scopus.com/inward/record.url?scp=0024836271&partnerID=8YFLogxK
U2 - 10.1016/0277-5379(89)90346-5
DO - 10.1016/0277-5379(89)90346-5
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AN - SCOPUS:0024836271
SN - 0277-5379
VL - 25
SP - 1765
EP - 1768
JO - European Journal of Cancer and Clinical Oncology
JF - European Journal of Cancer and Clinical Oncology
IS - 12
ER -
