SOCS1 in cancer: An oncogene and a tumor suppressor

Claudia Beaurivage, Audrey Champagne, William S. Tobelaim, Véronique Pomerleau, Alfredo Menendez, Caroline Saucier*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The Suppressor Of Cytokine Signaling 1 (SOCS1) has been extensively investigated in immune cells where it works as a potent inhibitor of inflammation by negative feedback regulation of the cytokine-activated JAK-STAT signaling pathways. SOCS1 is also recognized as a tumor suppressor in numerous cancers and its critical functional relevance in non-immune cells, including epithelial cells, has just begun to emerge. Most notably, conflicting results from clinical and experimental studies suggest that SOCS1 may function as either a tumor suppressor or a tumor promoter, in a cell context-dependent manner. Here, we present an overview of the mechanisms underlying SOCS1 function as a tumor suppressor and discuss the emerging evidences of SOCS1 activity as an oncogene.

Original languageEnglish
Pages (from-to)87-94
Number of pages8
StatePublished - 1 Jun 2016
Externally publishedYes


  • Cancer
  • Colorectal cancer
  • Cytokine
  • Oncogene
  • SOCS1
  • Tumor suppressor


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