SOCS1 in cancer: An oncogene and a tumor suppressor

Claudia Beaurivage; Audrey Champagne; William S. Tobelaim; Véronique Pomerleau; Alfredo Menendez; Caroline Saucier

doi:10.1016/j.cyto.2016.01.005

SOCS1 in cancer: An oncogene and a tumor suppressor

Claudia Beaurivage, Audrey Champagne, William S. Tobelaim, Véronique Pomerleau, Alfredo Menendez, Caroline Saucier^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The Suppressor Of Cytokine Signaling 1 (SOCS1) has been extensively investigated in immune cells where it works as a potent inhibitor of inflammation by negative feedback regulation of the cytokine-activated JAK-STAT signaling pathways. SOCS1 is also recognized as a tumor suppressor in numerous cancers and its critical functional relevance in non-immune cells, including epithelial cells, has just begun to emerge. Most notably, conflicting results from clinical and experimental studies suggest that SOCS1 may function as either a tumor suppressor or a tumor promoter, in a cell context-dependent manner. Here, we present an overview of the mechanisms underlying SOCS1 function as a tumor suppressor and discuss the emerging evidences of SOCS1 activity as an oncogene.

Original language	English
Pages (from-to)	87-94
Number of pages	8
Journal	Cytokine
Volume	82
DOIs	https://doi.org/10.1016/j.cyto.2016.01.005
State	Published - 1 Jun 2016
Externally published	Yes

Keywords

Cancer
Colorectal cancer
Cytokine
Oncogene
SOCS1
Tumor suppressor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cyto.2016.01.005

Cite this

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title = "SOCS1 in cancer: An oncogene and a tumor suppressor",

abstract = "The Suppressor Of Cytokine Signaling 1 (SOCS1) has been extensively investigated in immune cells where it works as a potent inhibitor of inflammation by negative feedback regulation of the cytokine-activated JAK-STAT signaling pathways. SOCS1 is also recognized as a tumor suppressor in numerous cancers and its critical functional relevance in non-immune cells, including epithelial cells, has just begun to emerge. Most notably, conflicting results from clinical and experimental studies suggest that SOCS1 may function as either a tumor suppressor or a tumor promoter, in a cell context-dependent manner. Here, we present an overview of the mechanisms underlying SOCS1 function as a tumor suppressor and discuss the emerging evidences of SOCS1 activity as an oncogene.",

keywords = "Cancer, Colorectal cancer, Cytokine, Oncogene, SOCS1, Tumor suppressor",

author = "Claudia Beaurivage and Audrey Champagne and Tobelaim, {William S.} and V{\'e}ronique Pomerleau and Alfredo Menendez and Caroline Saucier",

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doi = "10.1016/j.cyto.2016.01.005",

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T2 - An oncogene and a tumor suppressor

AU - Beaurivage, Claudia

AU - Champagne, Audrey

AU - Tobelaim, William S.

AU - Pomerleau, Véronique

AU - Menendez, Alfredo

AU - Saucier, Caroline

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AB - The Suppressor Of Cytokine Signaling 1 (SOCS1) has been extensively investigated in immune cells where it works as a potent inhibitor of inflammation by negative feedback regulation of the cytokine-activated JAK-STAT signaling pathways. SOCS1 is also recognized as a tumor suppressor in numerous cancers and its critical functional relevance in non-immune cells, including epithelial cells, has just begun to emerge. Most notably, conflicting results from clinical and experimental studies suggest that SOCS1 may function as either a tumor suppressor or a tumor promoter, in a cell context-dependent manner. Here, we present an overview of the mechanisms underlying SOCS1 function as a tumor suppressor and discuss the emerging evidences of SOCS1 activity as an oncogene.

KW - Cancer

KW - Colorectal cancer

KW - Cytokine

KW - Oncogene

KW - SOCS1

KW - Tumor suppressor

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SOCS1 in cancer: An oncogene and a tumor suppressor

Abstract

Keywords

UN SDGs

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