Social variables predict gains in cognitive scores across the preschool years in children with birth weights 500 to 1250 grams

Brett J. Manley, Robin S. Roberts, Lex W. Doyle, Barbara Schmidt, Peter J. Anderson, Keith J. Barrington, Birgitta Böhm, Agneta Golan, Aleid G. Van Wassenaer-Leemhuis, Peter G. Davis, Judy D'Ilario, Janice Cairnie, Joanne Dix, Beth Anne Adams, Erin Warriner, Mee Hai Marie Kim, Brenda Argus, Catherine Callanan, Julianne Duff, Marion McDonaldElizabeth Asztalos, Denise Hohn, Maralyn Lacy, Ross Haslam, Christopher Barnett, Louise Goodchild, Rosslyn Marie Lontis, Simon Fraser, Julie Keng, Kerryn Saunders, Gillian Opie, Elaine Kelly, Heather Woods, Emma Marchant, Anne Marie Turner, Noni Davis, Emma Magrath, Amanda Williamson, Aida Bairam, Sylvie Belanger, Annie Fraser, Marc Blayney, Brigitte Lemyre, Jane Frank, Alfonso Solimano, Anne Synnes, Ruth E. Grunau, Philippa Hubber-Richard, Marilyn Rogers, Margot Mackay, Julianne Petrie-Thomas, Arsalan Butt, Aleid Van Wassenaer, Debbie Nuytemans, Bregje Houtzager, Loekie Van Sonderen, Rivka Regev, Netter Itzchack, Shmuel Arnon, Adiba Chalaf, Arne Ohlsson, Karel O'Brien, Anne Marie Hamilton, May Lee Chan, Koravangattu Sankaran, Pat Proctor, Esther Goldsch-Lerman, Graham Reynolds, Barbara Dromgool, Sandra Meskell, Vanessa Parr, Catherine Maher, Margaret Broom, Zsuzsoka Kecskes, Cathy Ringland, Douglas McMillan, Elizabeth Spellen, Reginald S. Sauve, Heather Christianson, Deborah Anseeuw-Deeks, Dianne Creighton, Jennifer Heath, Ruben Alvaro, Aaron Chiu, Ceceile Porter, Gloria Turner, Diane Moddemann, Naomi Granke, Karen Penner, Jane Bow, Antonius Mulder, Renske Wassenberg, Markus Van Der Hoeven, Maxine Clarke, Judy Parfitt, Kevin Parker, Chukwuma Nwaesei, Heather Ryan, Cory Saunders, Andreas Schulze, Inga Wermuth, Anne Hilgendorff, Andreas W. Flemmer, Eric Herlenius, Lena Legnevall, Hugo Lagercrantz, Derek Matthew, Wendy Amos, Suresh Tulsiani, Cherrie Tan-Dy, Marilyn Turner, Constance Phelan, Eric S. Shinwell, Michael Levine, Ada Juster-Reicher, May Khairy, Patricia Grier, Julie Vachon, Larissa Perepolkin, Sunil Kumar Sinha, Win Tin, Susan Fritz, Herve Walti, Diane Royer, Henry Halliday, David Millar, Clifford Mayes, Christopher McCusker, Olivia McLaughlin, Hubert Fahnenstich, Bettina Tillmann, Peter Weber, Unni Wariyar, Nicholas Embleton, Ravi Swamy, Hans U. Bucher, Jean Claude Fauchere, Vera Dietz, Chidambara Harikumar, Deborah Dewey, Michael Gent, William Fraser, Edmund Hey, Max Perlman, Kevin Thorpe, Shari Gray, Carole Chambers, Lorrie Costantini, Wendy Yacura, Erin McGean, Lori Scapinello

Research output: Contribution to journalArticlepeer-review

Abstract

Objective To determine the extent that social variables influence cognitive development of very low birth weight (VLBW) infants across the preschool years. Study design Participants were VLBW (500-1250 g) children enrolled in the Caffeine for Apnea of Prematurity randomized trial between 1999 and 2004. We investigated the relationships between 4 potential social advantages: higher maternal education, higher paternal education, caregiver employment, and 2 biologic parents in the same home'and gain in cognitive scores. Cognitive assessments were performed at the corrected ages of 18 months (Mental Development Index score on the Bayley Scales of Infant Development II) and 5 years (Full Scale IQ on the Wechsler Preschool and Primary Scale of Intelligence III). Cognitive gain was computed by subtracting each individual 18-month Mental Development Index score from the corresponding Full Scale IQ at 5 years. Results Data were available for 1347 children. Mean (SD) cognitive scores were 90.8 (15.7) at 18 months and 98.9 (14.5) at 5 years. Multivariable regression showed that higher maternal education, higher paternal education, and caregiver employment had independent and additive effects of similar size on cognitive gain (P < .001); the mean cognitive gain between 18 months and 5 years increased by 3.6 points in the presence of each of these advantages. When all 3 were present, cognitive scores improved on average by 10.9 points compared with children without any of these advantages. Conclusion In VLBW children, a count of 3 social advantages strongly predicts gains in cognitive scores across the preschool years.

Original languageEnglish
Pages (from-to)870-876.e2
JournalJournal of Pediatrics
Volume166
Issue number4
DOIs
StatePublished - 2015
Externally publishedYes

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