Social isolation causes downregulation of immune and stress response genes and behavioural changes in a social insect

Inon Scharf, Marah Stoldt, Romain Libbrecht, Anna Lena Höpfner, Evelien Jongepier, Marion Kever, Susanne Foitzik

Research output: Contribution to journalArticlepeer-review

Abstract

Humans and other social mammals experience isolation from their group as stressful, triggering behavioural and physiological anomalies that reduce fitness. While social isolation has been intensely studied in social mammals, it is less clear how social insects, which evolved sociality independently, respond to isolation. Here we examined whether the typical mammalian responses to social isolation, e.g., an impaired ability to interact socially and immune suppression are also found in social insects. We studied the consequences of social isolation on behaviour and brain gene expression in the ant Temnothorax nylanderi. Following isolation, workers interacted moderately less with adult nestmates, increased the duration of brood contact, and reduced the time spent self-grooming, an important sanitary behaviour. Our brain transcriptome analysis revealed that only a few behaviour-related genes had altered their expression with isolation time. Rather, many genes linked to immune system functioning and stress response had been downregulated. This probably sensitizes isolated individuals to various stressors, in particular because isolated workers exhibit reduced sanitary behaviour. We provide evidence of the diverse consequences of social isolation in social insects, some of which resemble those found in social mammals, suggesting a general link between social well-being, stress tolerance, and immune competence in social animals.

Original languageEnglish
Pages (from-to)2378-2389
Number of pages12
JournalMolecular Ecology
Volume30
Issue number10
DOIs
StatePublished - May 2021

Keywords

  • Temnothorax
  • immune suppression
  • social insects
  • stress
  • transcriptomics

Fingerprint

Dive into the research topics of 'Social isolation causes downregulation of immune and stress response genes and behavioural changes in a social insect'. Together they form a unique fingerprint.

Cite this