TY - GEN
T1 - SNP and Haplotype analysis - Algorithms and applications
AU - Halperin, Eran
PY - 2006
Y1 - 2006
N2 - The recent release of the Haplotype Mapping project (Nature, Oct. 26, 2005 - see also, e.g., NY Times, Oct. 27), and the rapid reduction in genotyping costs open new directions and opportunities in the study of complex genetic disease such as cancer or Alzheimer's disease. The datasets collected for these studies are DNA sequences, with some noise and ambiguous information. In this talk I will discuss some of the algorithmic issues of disambiguating these DNA sequences, and the current and potential impact of these algorithms on genetics and medicine. In particular, I will discuss some of the problems in the field, such as genotype phasing, tag SNP selection (e.g. feature selection), and population stratification issues (e.g. clustering). The talk will be self contained, although some introductory material for the biological terminology and the HapMap project can be found at http://www.hapmap.org/whatishapmap.html.
AB - The recent release of the Haplotype Mapping project (Nature, Oct. 26, 2005 - see also, e.g., NY Times, Oct. 27), and the rapid reduction in genotyping costs open new directions and opportunities in the study of complex genetic disease such as cancer or Alzheimer's disease. The datasets collected for these studies are DNA sequences, with some noise and ambiguous information. In this talk I will discuss some of the algorithmic issues of disambiguating these DNA sequences, and the current and potential impact of these algorithms on genetics and medicine. In particular, I will discuss some of the problems in the field, such as genotype phasing, tag SNP selection (e.g. feature selection), and population stratification issues (e.g. clustering). The talk will be self contained, although some introductory material for the biological terminology and the HapMap project can be found at http://www.hapmap.org/whatishapmap.html.
UR - http://www.scopus.com/inward/record.url?scp=33746097395&partnerID=8YFLogxK
U2 - 10.1007/11780441_2
DO - 10.1007/11780441_2
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AN - SCOPUS:33746097395
SN - 3540354557
SN - 9783540354550
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 11
BT - Combinatorial Pattern Matching - 17th Annual Symposium, CPM 2006, Proceedings
PB - Springer Verlag
T2 - 17th Annual Symposium on Combinatorial Pattern Matching, CPM 2006
Y2 - 5 July 2006 through 7 July 2006
ER -
