Smoking and COVID-19: Similar bronchial ACE2 and TMPRSS2 expression and higher TMPRSS4 expression in current versus never smokers

Keyphrases

• Never-smokers 100%
• Angiotensin-converting Enzyme 2 (ACE2) 100%
• Transmembrane Protease Serine 2 (TMPRSS2) 100%
• COVID-19 100%
• TMPRSS4 100%
• Smokers 50%
• Protease 33%
• Bronchial Epithelial Cells 33%
• Current Smokers 33%
• Cell Entry 33%
• MRNA Level 16%
• Spike Protein 16%
• Pathophysiology 16%
• Epidemiological Study 16%
• Smoke Effect 16%
• Nicotine 16%
• Expression Level 16%
• Recognition Site 16%
• Controlled Experiment 16%
• Cigarette Smoking 16%
• Protective Effect 16%
• Serine Protease 16%
• Epidemiology 16%
• Nitric Oxide 16%
• RNA Expression 16%
• Infection Risk 16%
• Airway 16%
• Potential Therapeutics 16%
• Cell Recognition 16%
• Infected Individual 16%
• Cytokine Storm 16%
• Membrane Shedding 16%
• ADAM17 16%
• COVID-19 Hospitalization 16%
• Severe COVID-19 16%
• Expression Files 16%
• COVID-19 Severity 16%
• NCBI GEO 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Severe Acute Respiratory Syndrome 100%
• Proteinase 66%
• Infection 33%
• Pathophysiology 33%
• Controlled Clinical Trial 33%
• Nitric Oxide 33%
• Serine Proteinase 33%
• Cytokine Storm 33%
• SARS Coronavirus 33%
• Tumor Necrosis Factor Alpha Converting Enzyme 33%
• Messenger RNA 33%

Immunology and Microbiology

• COVID-19 100%
• Severe Acute Respiratory Syndrome 60%
• Spike 20%
• Data Mining 20%
• Cytokine Storm 20%
• ADAM17 20%
• Severe Acute Respiratory Syndrome Coronavirus 2 20%
• Serine 20%
• Airway 20%