Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia

Mark W. Logue; Sanne J.H. van Rooij; Emily L. Dennis; Sarah L. Davis; Jasmeet P. Hayes; Jennifer S. Stevens; Maria Densmore; Courtney C. Haswell; Jonathan Ipser; Saskia B.J. Koch; Mayuresh Korgaonkar; Lauren A.M. Lebois; Matthew Peverill; Justin T. Baker; Premika S.W. Boedhoe; Jessie L. Frijling; Staci A. Gruber; Ilan Harpaz-Rotem; Neda Jahanshad; Sheri Koopowitz; Ifat Levy; Laura Nawijn; Lauren O'Connor; Miranda Olff; David H. Salat; Margaret A. Sheridan; Jeffrey M. Spielberg; Mirjam van Zuiden; Sherry R. Winternitz; Jonathan D. Wolff; Erika J. Wolf; Xin Wang; Kristen Wrocklage; Chadi G. Abdallah; Richard A. Bryant; Elbert Geuze; Tanja Jovanovic; Milissa L. Kaufman; Anthony P. King; John H. Krystal; Jim Lagopoulos; Maxwell Bennett; Ruth Lanius; Israel Liberzon; Regina E. McGlinchey; Katie A. McLaughlin; William P. Milberg; Mark W. Miller; Kerry J. Ressler; Dick J. Veltman; Dan J. Stein; Kathleen Thomaes; Paul M. Thompson; Rajendra A. Morey

doi:10.1016/j.biopsych.2017.09.006

Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia

Mark W. Logue, Sanne J.H. van Rooij, Emily L. Dennis, Sarah L. Davis, Jasmeet P. Hayes, Jennifer S. Stevens, Maria Densmore, Courtney C. Haswell, Jonathan Ipser, Saskia B.J. Koch, Mayuresh Korgaonkar, Lauren A.M. Lebois, Matthew Peverill, Justin T. Baker, Premika S.W. Boedhoe, Jessie L. Frijling, Staci A. Gruber, Ilan Harpaz-Rotem, Neda Jahanshad, Sheri KoopowitzIfat Levy, Laura Nawijn, Lauren O'Connor, Miranda Olff, David H. Salat, Margaret A. Sheridan, Jeffrey M. Spielberg, Mirjam van Zuiden, Sherry R. Winternitz, Jonathan D. Wolff, Erika J. Wolf, Xin Wang, Kristen Wrocklage, Chadi G. Abdallah, Richard A. Bryant, Elbert Geuze, Tanja Jovanovic, Milissa L. Kaufman, Anthony P. King, John H. Krystal, Jim Lagopoulos, Maxwell Bennett, Ruth Lanius, Israel Liberzon, Regina E. McGlinchey, Katie A. McLaughlin, William P. Milberg, Mark W. Miller, Kerry J. Ressler, Dick J. Veltman, Dan J. Stein, Kathleen Thomaes, Paul M. Thompson, Rajendra A. Morey^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

356 Scopus citations

Abstract

Background Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)–Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. Methods We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. Results In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = −0.17, p =.00054), and smaller amygdalae (d = −0.11, p =.025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p <.0063). Conclusions Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.

Original language	English
Pages (from-to)	244-253
Number of pages	10
Journal	Biological Psychiatry
Volume	83
Issue number	3
DOIs	https://doi.org/10.1016/j.biopsych.2017.09.006
State	Published - 1 Feb 2018
Externally published	Yes

Funding

Funders	Funder number
Anonymous Women’s Health Fund McLean Hospital
Canadian Institute for Military and Veteran Health Research
Child Health Research Award
Frazier Foundation
O’Keefe Family Foundation
Charles H. Hood Foundation
VA National Center for PTSD
Brain and Behavior Research Foundation
Center for Computation in Medicine and Biology
Dutch Ministry of Defence
Canadian Institutes of Health Research
National Institute of Mental Health	R21MH112956, R21MH098212, F32MH109274, U01MH109536, K01MH092526, 1I01CX000748-01A1, R01MH111671, R01MH103291, R01MH106482, 1I01RX000389-01, R21MH102834, F32MH101976, R01MH071537, R01MH106595, K23MH073091
Biomedical Laboratory Research and Development, VA Office of Research and Development	B9254-C
National Institute of Biomedical Imaging and Bioengineering	P41EB015922, U54EB020403
National Institute on Aging	R01AG050595
U.S. Department of Defense	W81XWH-12-2-0012
National Center for Advancing Translational Sciences	UL1TR000454, UL1TR002378
Telecommunication and Advanced Technology Research Center	W81XWH-08-2-0208
U.S. Department of Veterans Affairs	I01CX000120, I01CX000748, I01RX000389, I01BX003477
Bill and Melinda Gates Foundation	OPP 1017641
National Center for Research Resources	M01RR000039
National Institute of Neurological Disorders and Stroke	U54NS100064, R01NS086885
National Health and Medical Research Council	1073041
ZonMw	100-020-002, 40-00812-98-10041, 110614

Keywords

Amygdala
Childhood trauma
Gender differences
Hippocampus
PTSD
Structural MRI

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10.1016/j.biopsych.2017.09.006

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Logue, M. W., van Rooij, S. J. H., Dennis, E. L., Davis, S. L., Hayes, J. P., Stevens, J. S., Densmore, M., Haswell, C. C., Ipser, J., Koch, S. B. J., Korgaonkar, M., Lebois, L. A. M., Peverill, M., Baker, J. T., Boedhoe, P. S. W., Frijling, J. L., Gruber, S. A., Harpaz-Rotem, I., Jahanshad, N., ... Morey, R. A. (2018). Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia. Biological Psychiatry, 83(3), 244-253. https://doi.org/10.1016/j.biopsych.2017.09.006

@article{e9317810f64b41648ff3da573d875cff,

title = "Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia",

abstract = "Background Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)–Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. Methods We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. Results In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = −0.17, p =.00054), and smaller amygdalae (d = −0.11, p =.025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p <.0063). Conclusions Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.",

keywords = "Amygdala, Childhood trauma, Gender differences, Hippocampus, PTSD, Structural MRI",

author = "Logue, {Mark W.} and {van Rooij}, {Sanne J.H.} and Dennis, {Emily L.} and Davis, {Sarah L.} and Hayes, {Jasmeet P.} and Stevens, {Jennifer S.} and Maria Densmore and Haswell, {Courtney C.} and Jonathan Ipser and Koch, {Saskia B.J.} and Mayuresh Korgaonkar and Lebois, {Lauren A.M.} and Matthew Peverill and Baker, {Justin T.} and Boedhoe, {Premika S.W.} and Frijling, {Jessie L.} and Gruber, {Staci A.} and Ilan Harpaz-Rotem and Neda Jahanshad and Sheri Koopowitz and Ifat Levy and Laura Nawijn and Lauren O'Connor and Miranda Olff and Salat, {David H.} and Sheridan, {Margaret A.} and Spielberg, {Jeffrey M.} and {van Zuiden}, Mirjam and Winternitz, {Sherry R.} and Wolff, {Jonathan D.} and Wolf, {Erika J.} and Xin Wang and Kristen Wrocklage and Abdallah, {Chadi G.} and Bryant, {Richard A.} and Elbert Geuze and Tanja Jovanovic and Kaufman, {Milissa L.} and King, {Anthony P.} and Krystal, {John H.} and Jim Lagopoulos and Maxwell Bennett and Ruth Lanius and Israel Liberzon and McGlinchey, {Regina E.} and McLaughlin, {Katie A.} and Milberg, {William P.} and Miller, {Mark W.} and Ressler, {Kerry J.} and Veltman, {Dick J.} and Stein, {Dan J.} and Kathleen Thomaes and Thompson, {Paul M.} and Morey, {Rajendra A.}",

note = "Publisher Copyright: {\textcopyright} 2017",

year = "2018",

month = feb,

day = "1",

doi = "10.1016/j.biopsych.2017.09.006",

language = "אנגלית",

volume = "83",

pages = "244--253",

journal = "Biological Psychiatry",

issn = "0006-3223",

publisher = "Elsevier Inc.",

number = "3",

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Logue, MW, van Rooij, SJH, Dennis, EL, Davis, SL, Hayes, JP, Stevens, JS, Densmore, M, Haswell, CC, Ipser, J, Koch, SBJ, Korgaonkar, M, Lebois, LAM, Peverill, M, Baker, JT, Boedhoe, PSW, Frijling, JL, Gruber, SA, Harpaz-Rotem, I, Jahanshad, N, Koopowitz, S, Levy, I, Nawijn, L, O'Connor, L, Olff, M, Salat, DH, Sheridan, MA, Spielberg, JM, van Zuiden, M, Winternitz, SR, Wolff, JD, Wolf, EJ, Wang, X, Wrocklage, K, Abdallah, CG, Bryant, RA, Geuze, E, Jovanovic, T, Kaufman, ML, King, AP, Krystal, JH, Lagopoulos, J, Bennett, M, Lanius, R, Liberzon, I, McGlinchey, RE, McLaughlin, KA, Milberg, WP, Miller, MW, Ressler, KJ, Veltman, DJ, Stein, DJ, Thomaes, K, Thompson, PM & Morey, RA 2018, 'Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia', Biological Psychiatry, vol. 83, no. 3, pp. 244-253. https://doi.org/10.1016/j.biopsych.2017.09.006

TY - JOUR

T1 - Smaller Hippocampal Volume in Posttraumatic Stress Disorder

T2 - A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia

AU - Logue, Mark W.

AU - van Rooij, Sanne J.H.

AU - Dennis, Emily L.

AU - Davis, Sarah L.

AU - Hayes, Jasmeet P.

AU - Stevens, Jennifer S.

AU - Densmore, Maria

AU - Haswell, Courtney C.

AU - Ipser, Jonathan

AU - Koch, Saskia B.J.

AU - Korgaonkar, Mayuresh

AU - Lebois, Lauren A.M.

AU - Peverill, Matthew

AU - Baker, Justin T.

AU - Boedhoe, Premika S.W.

AU - Frijling, Jessie L.

AU - Gruber, Staci A.

AU - Harpaz-Rotem, Ilan

AU - Jahanshad, Neda

AU - Koopowitz, Sheri

AU - Levy, Ifat

AU - Nawijn, Laura

AU - O'Connor, Lauren

AU - Olff, Miranda

AU - Salat, David H.

AU - Sheridan, Margaret A.

AU - Spielberg, Jeffrey M.

AU - van Zuiden, Mirjam

AU - Winternitz, Sherry R.

AU - Wolff, Jonathan D.

AU - Wolf, Erika J.

AU - Wang, Xin

AU - Wrocklage, Kristen

AU - Abdallah, Chadi G.

AU - Bryant, Richard A.

AU - Geuze, Elbert

AU - Jovanovic, Tanja

AU - Kaufman, Milissa L.

AU - King, Anthony P.

AU - Krystal, John H.

AU - Lagopoulos, Jim

AU - Bennett, Maxwell

AU - Lanius, Ruth

AU - Liberzon, Israel

AU - McGlinchey, Regina E.

AU - McLaughlin, Katie A.

AU - Milberg, William P.

AU - Miller, Mark W.

AU - Ressler, Kerry J.

AU - Veltman, Dick J.

AU - Stein, Dan J.

AU - Thomaes, Kathleen

AU - Thompson, Paul M.

AU - Morey, Rajendra A.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Background Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)–Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. Methods We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. Results In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = −0.17, p =.00054), and smaller amygdalae (d = −0.11, p =.025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p <.0063). Conclusions Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.

AB - Background Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)–Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. Methods We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. Results In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = −0.17, p =.00054), and smaller amygdalae (d = −0.11, p =.025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p <.0063). Conclusions Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.

KW - Amygdala

KW - Childhood trauma

KW - Gender differences

KW - Hippocampus

KW - PTSD

KW - Structural MRI

UR - http://www.scopus.com/inward/record.url?scp=85034845116&partnerID=8YFLogxK

U2 - 10.1016/j.biopsych.2017.09.006

DO - 10.1016/j.biopsych.2017.09.006

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C2 - 29217296

AN - SCOPUS:85034845116

SN - 0006-3223

VL - 83

SP - 244

EP - 253

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 3

ER -

Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia

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Keywords

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