Small-fiber neuropathy definition, diagnosis, and treatment

Natalia Y. Basantsova; Anna A. Starshinova; Amir Dori; Yulia S. Zinchenko; Piotr K. Yablonskiy; Yehuda Shoenfeld

doi:10.1007/s10072-019-03871-x

Small-fiber neuropathy definition, diagnosis, and treatment

Natalia Y. Basantsova, Anna A. Starshinova^*, Amir Dori, Yulia S. Zinchenko, Piotr K. Yablonskiy, Yehuda Shoenfeld

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Review article › peer-review

Abstract

In the last 30 years, improvement of diagnostic methods enabled routine evaluation of small A-delta and C nerve fibers impairment, which results with the clinical condition known as a small-fiber neuropathy (SFN). This syndrome develops as a result of metabolic, toxic, immune-mediated, or genetic factors. The main clinical features include neuropathic pain and autonomic disturbance, which are occasionally disclaimed due to outstanding fatigue, daily performance decline, anxiety, and depression. As clinical, neurological, nerve conduction, and electromyography studies are commonly normal, diagnosis often depends on the finding of decreased intra-epidermal density of nerve fibers, per skin biopsy. This review highlights the etiology, clinical, diagnostic aspects, and SFN treatment.

Original language	English
Pages (from-to)	1343-1350
Number of pages	8
Journal	Neurological Sciences
Volume	40
Issue number	7
DOIs	https://doi.org/10.1007/s10072-019-03871-x
State	Published - 1 Jul 2019

Keywords

Autoimmune diseases
Neuropathic pain
Sarcoidosis
Small-fiber neuropathy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10072-019-03871-x

Cite this

@article{615709931ccb4db0abcc46610becd702,

title = "Small-fiber neuropathy definition, diagnosis, and treatment",

abstract = "In the last 30 years, improvement of diagnostic methods enabled routine evaluation of small A-delta and C nerve fibers impairment, which results with the clinical condition known as a small-fiber neuropathy (SFN). This syndrome develops as a result of metabolic, toxic, immune-mediated, or genetic factors. The main clinical features include neuropathic pain and autonomic disturbance, which are occasionally disclaimed due to outstanding fatigue, daily performance decline, anxiety, and depression. As clinical, neurological, nerve conduction, and electromyography studies are commonly normal, diagnosis often depends on the finding of decreased intra-epidermal density of nerve fibers, per skin biopsy. This review highlights the etiology, clinical, diagnostic aspects, and SFN treatment.",

keywords = "Autoimmune diseases, Neuropathic pain, Sarcoidosis, Small-fiber neuropathy",

author = "Basantsova, {Natalia Y.} and Starshinova, {Anna A.} and Amir Dori and Zinchenko, {Yulia S.} and Yablonskiy, {Piotr K.} and Yehuda Shoenfeld",

note = "Publisher Copyright: {\textcopyright} 2019, Fondazione Societ{\`a} Italiana di Neurologia.",

year = "2019",

month = jul,

day = "1",

doi = "10.1007/s10072-019-03871-x",

language = "אנגלית",

volume = "40",

pages = "1343--1350",

journal = "Neurological Sciences",

issn = "1590-1874",

publisher = "Springer-Verlag Italia",

number = "7",

}

TY - JOUR

T1 - Small-fiber neuropathy definition, diagnosis, and treatment

AU - Basantsova, Natalia Y.

AU - Starshinova, Anna A.

AU - Dori, Amir

AU - Zinchenko, Yulia S.

AU - Yablonskiy, Piotr K.

AU - Shoenfeld, Yehuda

PY - 2019/7/1

Y1 - 2019/7/1

N2 - In the last 30 years, improvement of diagnostic methods enabled routine evaluation of small A-delta and C nerve fibers impairment, which results with the clinical condition known as a small-fiber neuropathy (SFN). This syndrome develops as a result of metabolic, toxic, immune-mediated, or genetic factors. The main clinical features include neuropathic pain and autonomic disturbance, which are occasionally disclaimed due to outstanding fatigue, daily performance decline, anxiety, and depression. As clinical, neurological, nerve conduction, and electromyography studies are commonly normal, diagnosis often depends on the finding of decreased intra-epidermal density of nerve fibers, per skin biopsy. This review highlights the etiology, clinical, diagnostic aspects, and SFN treatment.

AB - In the last 30 years, improvement of diagnostic methods enabled routine evaluation of small A-delta and C nerve fibers impairment, which results with the clinical condition known as a small-fiber neuropathy (SFN). This syndrome develops as a result of metabolic, toxic, immune-mediated, or genetic factors. The main clinical features include neuropathic pain and autonomic disturbance, which are occasionally disclaimed due to outstanding fatigue, daily performance decline, anxiety, and depression. As clinical, neurological, nerve conduction, and electromyography studies are commonly normal, diagnosis often depends on the finding of decreased intra-epidermal density of nerve fibers, per skin biopsy. This review highlights the etiology, clinical, diagnostic aspects, and SFN treatment.

KW - Autoimmune diseases

KW - Neuropathic pain

KW - Sarcoidosis

KW - Small-fiber neuropathy

UR - http://www.scopus.com/inward/record.url?scp=85067573250&partnerID=8YFLogxK

U2 - 10.1007/s10072-019-03871-x

DO - 10.1007/s10072-019-03871-x

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???

AN - SCOPUS:85067573250

SN - 1590-1874

VL - 40

SP - 1343

EP - 1350

JO - Neurological Sciences

JF - Neurological Sciences

IS - 7

ER -

Small-fiber neuropathy definition, diagnosis, and treatment

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this