Small-fiber neuropathy definition, diagnosis, and treatment

Natalia Y. Basantsova, Anna A. Starshinova*, Amir Dori, Yulia S. Zinchenko, Piotr K. Yablonskiy, Yehuda Shoenfeld

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


In the last 30 years, improvement of diagnostic methods enabled routine evaluation of small A-delta and C nerve fibers impairment, which results with the clinical condition known as a small-fiber neuropathy (SFN). This syndrome develops as a result of metabolic, toxic, immune-mediated, or genetic factors. The main clinical features include neuropathic pain and autonomic disturbance, which are occasionally disclaimed due to outstanding fatigue, daily performance decline, anxiety, and depression. As clinical, neurological, nerve conduction, and electromyography studies are commonly normal, diagnosis often depends on the finding of decreased intra-epidermal density of nerve fibers, per skin biopsy. This review highlights the etiology, clinical, diagnostic aspects, and SFN treatment.

Original languageEnglish
Pages (from-to)1343-1350
Number of pages8
JournalNeurological Sciences
Issue number7
StatePublished - 1 Jul 2019


  • Autoimmune diseases
  • Neuropathic pain
  • Sarcoidosis
  • Small-fiber neuropathy


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