Sleep Disturbances Can Be Prospectively Observed in Patients with an Inactive Inflammatory Bowel Disease

Ariella Bar-Gil Shitrit*, Chen Chen-Shuali, Tomer Adar, Benjamin Koslowsky, Shimon Shteingart, Kalman Paz, Sorina Grisaru-Granovsky, Eran Goldin, Gali Epstein Shochet, David Shitrit

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Poor sleep quality is associated with adverse health consequences. Sleep disturbances can impact the immune function and inflammatory processes. Little is known about sleep disturbances in patients with inflammatory bowel disease (IBD), while not in flare, i.e., inactive. Aims: To prospectively explore the sleep quality of patients with an inactive IBD. Methods: This pilot study included 36 consecutive patients with IBD and 27 healthy volunteers. All IBD patients had an inactive disease. Participants underwent an overnight ambulatory polysomnography. Data on disease duration, medications, complications, and treatment were collected from the medical records. Results: The mean age of the IBD and the control groups was 39 ± 15 and 34.6 ± 9.6 years. A significantly less rapid eye movement (REM) sleep was noted in the IBD group vs. control (23.7 vs. 27.8%, p = 0.047); light sleep percentage and REM latency were also longer in the IBD group. Moreover, oxygen desaturation below 90% was more common in the IBD group. All other sleep parameters including respiratory disturbance index, apnea–hypopnea index, number of wakes, sleep latency, and snoring strength were similar in both groups. Conclusions: Inactive IBD is associated with sleep disturbances. A larger prospective study should be conducted to confirm these findings.

Original languageEnglish
Pages (from-to)2992-2997
Number of pages6
JournalDigestive Diseases and Sciences
Issue number11
StatePublished - 1 Nov 2018


  • Crohn’s disease
  • Inflammatory bowel disease
  • Oximetry
  • Polysomnography
  • Sleep


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